ALZHEIMER'S DISEASE NEUROIMAGING INITIATIVE (ADNI): PROTOCOL ADNI-024, DATED

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 阿尔茨海默病神经影像学倡议（ADNI）研究是一项多中心生物标志物试验，旨在确定疾病进展的生物标志物，这些生物标志物最有希望作为预防和治疗AD的2期和3期临床试验的替代终点。 这是一项非随机自然史非治疗研究，将在美国和加拿大的约50个研究中心招募共计800例受试者，包括200例正常对照、400例轻度认知障碍（MCI）患者和200例轻度阿尔茨海默病（AD）受试者，进行纵向随访。MCI受试者和对照受试者将随访3年，AD受试者将随访2年。 在UCI，我们将招募48名受试者（24名MCI，12名轻度AD和12名正常人）。 总体目标是为当前和今后的分析收集所需数据，并进行一组有限的分析。所有临床数据将由加州大学圣地亚哥分校（UCSD）的协调中心收集、监测和储存。宾夕法尼亚大学（U Penn）将收集生物标志物样本。所有原始和处理后的图像数据将在神经影像实验室（LONI）存档。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Alzheimer s Disease Neuroimaging Initiative (ADNI) study is a multi-center biomarker trial to identify biomarkers of disease progression that are most promising as surrogate endpoints in phase 2 and 3 clinical trials for the prevention and treatment of AD. This is a non-randomized natural history non-treatment study in which a total of 800 subjects including 200 normal controls, 400 individuals with Mild Cognitive Impairment (MCI), and 200 subjects with mild Alzheimer s Disease (AD) will be recruited at approximately 50 sites in the United States and Canada for longitudinal follow up. Subjects with MCI and controls will be followed for 3 years, those with AD for 2 years. At UCI we will enroll 48 subjects (24 MCI, 12 Mild AD, and 12 normals). The overall objectives are to collect the required data for current and future analyses and to carry out a limited set of analyses. All clinical data will be collected, monitored, and stored by the Coordinating Center at University of California, San Diego (UCSD). University of Pennsylvania (U Penn) will collect biomarker samples. All raw and processed image data will be archived at the Laboratory of Neuroimaging (LONI).