ROLE OF MITOCHONDRIAL GENETIC VARIATIONS IN RECOVERY FROM STROKE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在美国，每年大约有75万新中风患者，中风患者以表现出不同程度的自发康复而臭名昭著。不幸的是，这样的康复往往是有限的，使中风成为美国成年人残疾的主要原因。治疗选择有限，中风患者的平均寿命为7年，导致美国有400多万中风幸存者存活，大多数患者都患有慢性神经损伤。因此，更好地了解中风康复的基础及其个体间的差异性，对于改进治疗方案可能非常重要。目前还没有针对慢性营养不良患者的经批准的治疗方法。局灶性中风后，神经功能的许多方面都会受到损害。最常见的损害领域是运动系统，绝大多数患者在中风后早期出现一侧或双侧无力。然而，这种恢复是高度可变的，在许多，也许是大多数中风患者中留下了某种程度的永久性运动障碍。因此，在美国和许多其他国家，中风是导致成年人残疾的主要原因。许多研究已经描述了中风后运动功能恢复的时间过程。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There are approximately 750,000 new strokes each year in the U.S and stroke patients are notorious in showing a variable degree of spontaneous recovery. Unfortunately, such recovery is often limited, making stroke the leading cause of adult disability in the U.S. There are limited therapeutic options and patients who survive stroke live an average of 7 years, leading to a prevalence of more than four million stroke survivors alive in the U.S, most patients are left with chronic neurological impairments. Hence, a better understanding of the basis for stroke recovery, and its inter-individual variability, could be of great importance to improving therapeutic options. There are currently no approved treatments that target patients with chronic deficits. Many aspects of neurological function can be impaired after a focal stroke. The most common domain of impairment is the motor system, with a large majority of patients having weakness on one or both sides early after stroke. This recovery is highly variable, however, leaving some degree of permanent motor deficit in many, and perhaps most stroke patients. As a result, stroke is the leading cause of adult disability in the U.S. and many other countries. A number of studies have described the time course by which motor function returns after a stroke.