ANALYSIS OF BONE HEALTH IN AFRICAN AMERICAN CHILDREN WITH DISTAL FOREARM

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 假设1：对环境概况、人体测量数据和饮食的分析将表明，与骨骼健康不良相关的流行病学风险因素与非裔美国儿童创伤性前臂骨折显著相关。 这些因素包括与维生素D缺乏和体重指数增加相关的因素。 我们将确定和比较各组的社会人口/环境概况、人体测量数据和饮食风险因素。 假设二：对维生素D缺乏症的生化指标的分析表明，至少有10%的创伤性前臂骨折的非洲裔美国儿童缺乏维生素D。 该特定目标的目的是识别和比较各组中亚临床维生素D缺乏/维生素D不足的存在。 假设三：双能X线骨密度仪（DEXA扫描）测量结果将证明，低骨密度和/或骨矿物质含量与非裔美国儿童创伤性前臂骨折相关。 使用DEXA扫描，我们将测量每个研究组的一个子集中的骨矿物质含量和密度。 该特定目标的目的是识别和比较各组中异常的骨矿物质含量和密度。 假设4：与非裔美国儿童相比，与骨骼健康/质量相关的基因的遗传多态性，如维生素D受体多态性，与创伤性前臂骨折的风险增加有关。 将使用GCRC遗传学核心，对个体进行与骨健康/质量相关的蛋白质多态性的基因分型。 将测试每种多态性与目标1-3中描述的与骨骼健康不良相关的因素之间的相关性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypothesis 1: An analysis of environmental profiles, anthropometric data and diet will demonstrate that epidemiological risk factors linked with poor bone health are significantly associated with traumatic forearm fractures in African American children. These include factors associated with vitamin D deficiency, and increased body mass index. We will identify and compare sociodemographic/environmental profiles, anthropometric data and dietary risk factors in the groups. Hypothesis 2: An analysis of biochemical indicators of Vitamin D deficiency will demonstrate that at least ten percent of African American children with traumatic forearm fractures have deficient levels. The goal of this specific aim is to identify and compare the presence of subclinical vitamin D deficiency/vitamin D insufficiency in each of the groups. Hypothesis 3: Dual energy x-ray absorptiometry (DEXA scan) measurements will demonstrate that low bone density and/or bone mineral content is associated with traumatic forearm fractures in African American children. Using DEXA scan, we will measure bone mineral content and density in a subset of each of the study groups. The goal of this specific aim is to identify and compare abnormal bone mineral content and density in each of the groups. Hypothesis 4: Genetic polymorphisms in genes related to bone health/quality, such as the vitamin D receptor polymorphism, are associated with increased risk of traumatic forearm fractures in African American children compared with fracture-free controls. Using the GCRC Genetics Core, genotyping of individuals for protein polymorphisms related to bone health/quality will be done. Testing for correlation between each polymorphism and factors associated with poor bone health described in aims 1-3 will be performed.