Advancing Physiological Signal Analysis for Mind-Body Research

描述（由申请人提供）：这个职业生涯中期发展奖将为博士提供保护的时间。虽然已经是一个成功的导师，证明了他的学员成为成功的NIH资助的院士，他的时间已经并将进一步限制缺乏任何工资支持的T32他指导。这个成功的T32目前有5名博士后和一名博士前候选人。博士前候选人是T32的第一个，她已经宣布奥肯博士是她的行为神经科学博士论文的主要导师。除了增加目前的导师角色外，K24还将允许Oken博士为他指导的T32开发正式课程，为非CAM临床研究和基础科学学员提供CAM相关讲座，并将时间分配给OHSU副院长正在开发的导师和职业发展计划。除了提供足够的资金来更好地指导他人之外，Oken博士还将把这个职业发展奖的很大一部分用于提高他的实验室的信号分析和采集能力，包括增强与个人数字助理接口的24小时记录设备的使用。这项开发将利用Mikel Aickin博士、Deniz Erdgomus博士和Roger Ellingson博士的技术支持。这些系统将提供给那些对这些技术感兴趣的T32和其他初级教师。一些职业发展基金将允许奥肯博士在波特兰州立大学学习研究生水平的系统科学课程。分析技术将有助于开发：一个坚持冥想干预和质量的生理测量;一个基于信息理论的电极间EEG相关性的测量，这可能比该领域其他人已经使用的参数同步测量更有效;以及一个24小时心率变异性的压力敏感测量。连接到24小时记录设备的个人数字助理允许在实验室外的受试者的通常环境中对与身心相关的自评测量进行频繁的基于经验的采样，例如感知压力和正念。这些测量将与使用系统科学方法的生理测量相关。 公共卫生相关性：该应用程序的总体目标是促进Oken博士更好地指导临床补充医学研究人员的能力，并推进身心研究领域。这将通过允许Oken博士减少他的一些行政和临床责任，并通过开发可用于身心研究的新生理措施来实现，包括压力措施，坚持干预措施和对大脑的积极影响。从实践的角度来看，这一应用将导致更多合格的年轻CAM临床研究人员和改善身心医学的临床试验。提高对身心医学益处的理解，甚至可能提高身心技术本身，对几乎所有的医疗保健和健康促进都有广泛的健康影响。

DESCRIPTION (provided by applicant): This mid-career development award will provide protected time for Dr. Oken to mentor and to advance his capability in physiological signal acquisition and analysis. While already a successful mentor, as evidenced by his mentees becoming successful NIH-funded academicians, his time has been and will be further limited by the lack of any salary support for the T32 he directs. This successful T32 currently has 5 post-doctoral and one pre-doctoral candidate. The pre-doctoral candidate is the first on the T32 and she has declared Dr Oken to be her primary mentor for her Behavioral Neuroscience PhD thesis. In addition to increasing current mentorship roles, the K24 will allow Dr. Oken to develop a formal curricula for the T32 he directs, give CAM-related lectures to non-CAM clinical research and basic science trainees, and to allocate time to the mentorship and career development program that the OHSU associate dean is developing. Besides sufficient funding to better mentor others, Dr. Oken will also spend a significant portion of this career development award advancing his lab's capability for signal analysis and acquisition including the enhanced use of a 24-hour recording device that is interfaced with a personal digital assistant. This development will utilize the technical support of Mikel Aickin, PhD, Deniz Erdgomus, PhD, and Roger Ellingson, MSEE. These systems will be available to those on the T32 and other junior faculty interested in these techniques. Some of the career development funds will allow Dr. Oken to take graduate level Systems Science courses at Portland State University. The analysis techniques will aid development of: a physiologic measure of adherence to and quality of meditation interventions; a measure of interelectrode EEG correlation based on information theory that is likely more valid than parametric synchrony measures already used by others in the field; and a stress- sensitive measure of 24-hour heart rate variability. The personal digital assistant interfaced to the 24-hour recording device allows for frequent, experience-based sampling of self-rated measures relevant to mind-body such as perceived stress and mindfulness outside the laboratory in the subject's usual environment. These measurements will be related to the physiological measurements using systems science approaches. PUBLIC HEALTH RELEVANCE: The general goal of this application is to promote Dr. Oken's ability to better mentor clinical complementary medicine researchers and to advance the field of mind-body research. This will be done by allowing Dr. Oken to decrease some of his administrative and clinical responsibilities and by developing new physiologic measures that can be used in mind-body research, including measures of stress, adherence to interventions, and positive effects on the brain. From a practical perspective this application will lead to more qualified young CAM clinical researchers and to improved clinical trials of mind-body medicine. Improved understanding of the benefits of mind-body medicine and possibly even improving mind-body techniques themselves has broad health implications to almost all medical care and health promotion.