CLEFT LIP GENETICS: A MULTICENTER INTERNATIONAL CONSORTIUM

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项多中心国际研究的目标是确定非综合征性唇腭裂的病因(S)。我们中心的作用是招募多个家庭(有两个或两个以上患有唇腭裂的家庭成员)和三人家庭(一个受影响的孩子和两个未受影响的父母)，获取病史和孕产史，以及用于基因研究的DNA样本。血液样本被送往利德拉尔博士在爱荷华大学的实验室进行DNA提取和基因分型研究。来自多重家族的样本将被纳入全基因组筛查，以识别包含在唇腭裂形成中重要基因的染色体区域。来自TRIO的样本将被用于连锁平衡失调研究，以证明哪些染色体区域对分裂是重要的。我们的目标包括每年招募20-30个多用途家庭和30-40个三人组。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this multicenter international study is to determine the cause(s) of nonsyndromic cleft lip and palate. Our center's role has been to recruit multiplex families (with two or more family members with cleft lip and/or palate) and trios (a single affected child and both unaffected parents), obtain medical and pregnancy history, and DNA samples for genetic studies. The blood sample is sent to Dr. Lidral's laboratory at the University of Iowa for DNA extraction and genotyping studies. Samples from the multiplex families will be incorporated into genome-wide screens to identify chromosomal regions containing a gene important in cleft lip/palate formation. Samples from trios will be used for linkage dysequilibrium studies to demonstrate which chromosome regions are important to clefting. Our goals include the recruitment of 20-30 multiplex families and 30-40 trios per year.