DISABILITY FROM PEDIATRIC TRAUMATIC BRAIN INJURY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在本项目中，我们将对患有TBI的儿童和青少年进行基于人群的监测。 通过该监测，我们将确定一个儿童TBI患者样本，这些患者将被招募并入组研究。 研究人群将是患有轻度、中度或重度TBI的>1周龄且小于18岁的儿童。我们将包括由于有意或无意原因造成的TBI。 该样本将按严重程度和年龄分层，以允许每个严重程度水平（包括轻度TBI）和每个年龄组有足够数量的个体用于研究。 将获得初始和基线测量结果，并随时间推移对患者进行随访，以确定TBI的结局。 我们还将招募一个对照组的儿童受伤以外的头部，作为一个比较，特别是对儿童轻度创伤性脑损伤。该分析将使我们能够计算不同年龄和严重程度下基于人群的TBI发病率，受伤后前36个月内TBI的残疾，以及与严重程度相互作用以影响结果的风险或保护因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this project, we will conduct a population-based surveillance of children and adolescents with TBI. From this surveillance, we will identify a sample of pediatric patients with TBI who will be recruited and enrolled in the study. The study population will be children >1 week old and less than 18 years with a mild, moderate or severe TBI. We will include TBI due to either intentional or unintentional causes. This sample will be stratified by severity and age to allow adequate numbers of individuals at each severity level (including mild TBI) and each age group for study. Initial and baseline measurements will be obtained, and patients will be followed over time to determine outcomes from TBI. We will also enroll a control group of children with injuries other than to the head, to serve as a comparison especially for children with mild TBI. The analysis will allow us to calculate population based incidence of TBI at different ages and severities, disability from TBI over the first 36 months following injury, and risk or protective factors which interact with severity to affect outcome.