CARDIOVASCULAR LINKAGE BETWEEN ENDOTHELIAL FUNCTION & AIR POLLUTION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 空气污染会增加患心脏病和血管疾病的风险。这项研究旨在提高我们对空气污染如何影响血管的理解。健康、不吸烟的成年人，年龄在18-50岁之间，无论性别、种族或民族，都将被招募来评估污染对血管功能、血压和血液实验室的影响。 每个受试者都将在呼吸含有自然大气中浓缩污染的空气2小时之前和之后立即通过超声波和抽血测试他们的血管功能。空气中的污染量与繁忙城市的污染程度相似。在过去的研究中，受试者无法区分“肮脏”的空气和干净的空气。暴露前一天和暴露后一天将佩戴血压监测袖带。在每次暴露前一小时，受试者将接受糖丸(安慰剂)、维生素C2g或降压药(博生坦500毫克)的预治疗。患者将在暴露后第二天返回进行抽血和血管功能测试。总共将有3次考察访问。在每次就诊期间，患者将暴露在相同的空气污染中，但将随机接受不同的治疗前药物治疗。 ‘

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Air pollution increases the risk for heart and vascular disease. This study is designed to improve our understanding of how air pollution effects blood vessels. Healthy, non-smoking adults, ages 18-50, of any gender, race or ethnicity, will be recruited to evaluate the impact of pollution on blood vessel function, blood pressure, and blood labs. Each subject will have their blood vessel function tested by an ultrasound and blood drawn before and immediately after breathing air that contains pollution concentrated from the natural atmosphere for 2 hours. The amount of pollution in the air is similar to that may be found in a busy city. In past studies subjects could not tell the difference between the "dirty" air and the clean air. A blood pressure monitoring cuff will be worn the day prior to and after the exposure. One hour prior to each exposure subjects will receive a pre-treatment of either a sugar pill (placebo), Vitamin C 2 g, or a blood pressure medication (Bosentan 500 mg). Patients will return the day after the exposure for a blood draw and a blood vessel function test. There will be a total of 3 study visits. During each visit patients will be exposed to the same air pollution, but will receive a different pre-treatment medication in random order. '