SLEEP DISORDERS AND IMMUNE RESPONSE TO THE FLU SHOT

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 本研究将评估流感免疫对自我报告睡眠习惯正常的受试者和睡眠障碍受试者的抗体反应性的有效性。该项目的总体目标是确定睡眠障碍是否会对免疫功能产生负面影响。我们将测定正常睡眠者和睡眠障碍受试者（包括失眠、昼夜节律紊乱（轮班工人）和阻塞性睡眠呼吸暂停受试者）的IgG抗体滴度。将从接种前以及接种后10天和30天采集的血样中测定抗体滴度。受试者将进行睡眠研究，以确认是否纳入适当的组，并记录睡眠和流感症状。睡眠障碍对免疫系统的有害影响，特别是对流感疫苗接种的抗体反应，最近在部分睡眠剥夺研究中得到了证实，其中睡眠剥夺的健康年轻人对免疫的抗体反应不到正常睡眠受试者的一半。尚未评估睡眠剥夺或睡眠障碍对普通人群免疫功能的影响。'

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will evaluate the effectiveness of influenza immunization on antibody responsiveness in subjects with normal self reported sleep habits and on those with sleep disorders. The general aim of this project is to determine whether sleep disorders negatively impact immune function. We will determine IgG antibody titers from normal sleepers and from subjects with disturbed sleep, including subjects with insomnia, circadian rhythm disorders (shift workers) and obstructive sleep apnea. Antibody titers will be determined from blood samples taken prior to vaccination and at 10 and 30 days after vaccination. Subjects will have a sleep study performed to confirm inclusion in the appropriate group, and keep logs of sleep and flu symptoms. The deleterious effects of sleep disorders on the immune system, and specifically antibody response to influenza vaccination, have been recently demonstrated in a partial sleep deprivation study, where sleep deprived healthy young adults had an antibody response to immunization of less than half the one of subjects with normal sleep. The impact on immune function of sleep deprivation or sleep disorders in the general population has not been evaluated.'