STEROID TIMING AND RENAL TRANSPLANATION (START) STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究是为了验证这样一种假设，即与早上服用泼尼松相比，晚上服用泼尼松会导致糖耐量正常的受试者胰岛素和血糖水平降低。为了评估夜间服用泼尼松的代谢益处，PI将在GCRC中对两名正常志愿者进行交叉研究，比较24小时内胰岛素和血糖的水平，这些志愿者在上午8点和晚上8点分别服用60毫克的泼尼松。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is to test the hypothesis that compared to giving prednisone in the morning; giving prednisone at night will result in lower insulin and glucose levels in subjects with normal glucose tolerance. To evaluate the metabolic benefit of giving prednisone at night, the PI will compare insulin and glucose levels over 24 hours in crossover studies on a regulated diet in the GCRC in 2 normal volunteers who receive a single 60 mg dose of prednisone at 8 am vs. 8 pm.