Preventive Interventions Leadership U01

描述（由申请人提供）：这个预防干预领导申请来自两个提交的U01研究申请。一项申请（C. Kemp and S. Hanash co- pi）提出研究乳腺癌和肺癌的小鼠模型，以确定适用于人类乳腺癌和肺癌的循环蛋白标记物。第二项研究（M. Disis、PI和S. Hanash，共同研究者）建议研究乳腺癌小鼠模型，以确定以自身抗体形式诱导免疫反应的肿瘤抗原，这些抗原可用于乳腺癌的早期诊断，并具有开发疫苗的潜力。领导应用团队在营养干预和能量平衡、化学预防、基因组和蛋白质组学研究方面增加了研究人员和资源。信息学资源和专业知识包括建模、软件和数据库开发，与NCI的癌症生物信息学网格（CaBIG）兼容，以及多维数据的综合分析。该研究计划设想了一个双重策略，一个是在小鼠模型中进行研究，以更好地理解来自全基因组关联研究（GWAS）和其他基因组研究的人类研究结果；化学预防研究的结果将受益于小鼠模型的进一步研究以及环境暴露、饮食和卡路里消耗研究的结果。第二种策略包括在小鼠模型中进行的研究，这些研究将导致后续的人类研究，并包括使用小鼠模型识别候选生物标志物，这些生物标志物将适用于早期检测和肿瘤复发评估；化学预防剂在小鼠模型中的检测以及在小鼠模型中鉴定肿瘤抗原，这些抗原可能适用于人类的早期检测和。疫苗开发的目标。领导团队还将通过促进预防集群内部的互动和联合活动，以及集群与其他NCI项目和更广泛的科学界之间的互动和联合活动，以及通过领导项目共享资源，为推进MMHHC的使命做出贡献。

DESCRIPTION (provided by applicant): This Preventive Interventions leadership application draws from two submitted U01 research applications. One application (C. Kemp and S. Hanash co-PIs) proposes to investigate mouse models of breast and lung cancer to Identify circulating protein markers applicable to breast and lung cancer in humans. The second (M. Disis, PI and S. Hanash, co-investigator) proposes to investigate mouse models of breast cancer to identify tumor antigens that induce an immune response in the form of autoantibodies that can be used for early diagnosis of breast cancer and that have potential for vaccine development. The team for the leadership application is augmented with investigators and resources in nutritional interventions and energy balance, chemoprevention, genomic and proteomic studies. Informatics resources and expertise include modeling, software and database development with the NCI's cancer bioinformatics grid (CaBIG) compatibility and integrative analysis of multi-dimensional data. The research program envisions a dual strategy, one consisting of studies in mouse models to better understand findings in humans stemming from genome-wide association studies (GWAS) and other genomic studies; findings from chemoprevention studies that benefit from further investigations using mouse models and findings from environmental exposures, diet and calorie expenditure studies. The second strategy consists of studies in mouse models that will lead to subsequent studies in humans and includes identification of candidate biomarkers using mouse models that would be applicable for early detection and for assessment of tumor recurrence; testing of chemoprevention agents in mouse models; and identification of tumor antigens in mouse models that are potentially applicable to humans for early detection and.of targets for vaccine development. The leadership team will also contribute to advancing the mission of MMHHC by facilitating interactions and joint activities within the Prevention Cluster and between clusters and other NCI programs and the broader scientific community and by sharing resources to be developed through the leadership program. RELEVANCE: There is a crucial need for innovative strategies for cancer prevention. We have assembled a multi-disciplinary team to take full advantage of the availability of mouse models of cancer to coordinate effort aimed at first testing strategies for cancer prevention in mouse models to make informed choices for cancer prevention in humans through nutritional intervention, through blood based screening and diagnosis and through boosting of the immune system to fight cancer at its earliest stages.