METABOLIC RESPONSE TO WESTERN VS INDIGENOUS DIETS IN HISPANIC WOMEN

摘要：这项建议侧重于了解西班牙裔女性的饮食模式与肥胖风险之间的关系。这是健康差距领域的一个重要问题，因为在美国，近80%的西班牙裔女性超重或肥胖，肥胖会增加患多种慢性病的风险，包括乳腺癌。该项目的总体目标是测试西裔和墨西哥本土饮食对西班牙裔妇女的代谢反应。我们还将调查祖先的遗传变异是否会调节对每种饮食的反应。我们假设，对西方饮食模式的生物反应会产生有利于脂肪沉积的有害代谢特征，从而导致不良健康事件的风险增加，包括乳腺癌风险的增加。相反，我们假设对墨西哥本土饮食的生理反应将产生有利的新陈代谢特征。我们进一步假设，遗传祖先对西方饮食模式的这种生物学反应起到了中介作用。我们的主要目标是：(1)在随机交叉实验喂养研究中，测试50名居住在大西雅图地区的第一代和第二代西班牙裔女性对墨西哥土著饮食和西方饮食的代谢反应。代谢反应将通过在每个饲养期前后评估的下列生物标志物的血液浓度来测量：胰岛素、葡萄糖、IGFI、IGFBP3、瘦素、脂联素、IL-6、CRP和SAA；以及(2)调查用祖先信息标记评估的遗传特征是否调节对每种受试饮食的代谢反应。作为次要的施舍，我们将检查每个饮食测试期的饥饿感和饱腹感，以及肥胖的遗传预测因素。该项目将为了解拉美裔女性肥胖的病因提供重要数据，可用于设计有效的预防方案。

Abstract: This proposal focuses on understanding the relationship between dietary patterns and risk of obesity in Hispanic women. This is an important issue in the realm of health disparities because neariy 80% of Hispanic women in the United States are ovenweight or obese and obesity increases risk for numerous chronic diseases, including breast cancer. The overall goal of this project Is to test the metabolic response to Western -and Indigenous Mexican diets in Hispanic women. We will also investigate whether ancestral genetic variation mediates the response to each diet. We hypothesize that the biological response to a Western dietary pattern produces detrimental metabolic profiles favoring adipose deposition, which leads to increased risk of adverse health events, including increased risk of breast cancer. Conversely, we hypothesize that the physiologic response to an Indigenous Mexican diet will produce a favorable metabolic profile. We further hypothesize that genetic ancestry mediates this biological response to a Western dietary pattern. Our primary aims are: (1) To test in a randomized cross-over experimental feeding study the metabolic response to an Indigenous Mexican diet vs. a Western diet in 50 first and second generation Hispanic women living in the greater Seattle area. The metabolic response will be measured by blood concentrations ofthe following biomarkers assessed before and after each feeding period: insulin, glucose, IGFI, IGFBP3, leptin, adiponectin, IL-6, CRP and SAA; and (2) To investigate whether genetic characteristics, as assessed with Ancestry Informative Markers, mediate the metabolic response to each tested diet. As secondary alms we will examine measures of hunger and satiety during each diet test period and genetic predictors of adiposity. This project will provide important data for understanding the etiology of obesity in i-lispanic women, which can be used to design effective programs for prevention.