Translational Training in Addiction

描述（由申请人提供）：本提案将在成瘾的转化研究这一新兴领域建立一个独特的培训项目。该领域有多种学科视角、程序、范式和技术来衡量或改变影响人类药物依赖发展、维持和停止的过程。接受转化研究培训的科学家将处于基础研究和临床研究的十字路口，在那里他们可以提供这两个领域之间的关键途径。学员的研究机会将包括：甲基苯丙胺滥用抗体疗法的实验室研究、成瘾行为经济学研究、治疗可卡因和阿片类药物依赖的新药物、大麻依赖的行为治疗、改变的行为和神经机制、治疗服务的传播以及减少药物治疗障碍的成本效益。该项目将培训成瘾科学家参与转化科学，直接评估基础研究的临床相关性；对药物滥用的基本过程进行科学分析；帮助开发和评估成瘾的行为和药物治疗；确定将这些发现纳入临床实践的方法；并确定支持集成的策略。该计划将大大加强先前培训的12名核心教师，谁是医学博士或博士在药理学和毒理学，精神病学，健康行为和健康促进部门的任命，并拥有22 NIDA， 3 N1AA, 1 N1CHD, 1 SAMSHA， 1 NIMH和16 VA研究资助。在这些核心学院培养的28名博士生和37名博士后中，86%的博士生和89%的博士后仍在从事研究/学术工作，49%的博士后学员担任教职。学员共发表论文500余篇，其中40%为第一作者，获得科研资助43项。这里提出的新项目将通过逐步增加招生人数，在拨款周期结束时培养5名博士预科生、7名博士后和19名医科学生。学员的选择将基于学习成绩优秀和对成瘾研究事业的承诺。培训将在成瘾研究中心进行。

DESCRIPTION (provided by applicant): This proposal will establish a unique training program in an emerging area-translational research in addiction. This field has a diverse set of disciplinary perspectives, procedures, paradigms, and technologies to measure or alter processes affecting development, maintenance, and cessation of drug dependence in humans. Scientists trained in translational research will be at the crossroads of basic and clinical research, where they can provide a crucial pathway between these two domains. Trainee research opportunities will include, among many others, laboratory studies of antibody-based therapy for methamphetamine abuse, studies of the behavioral economics of addiction, novel medications to treat cocaine and opiate dependence, behavioral treatments of marijuana dependence, behavioral and neural mechanisms of change, treatment service dissemination, and cost- effectiveness of reducing drug treatment barriers. The project will train addiction scientists to participate in translational science that directly assesses the clinical relevance of basic research; conducts scientific analyses of basic processes underlying drug abuse; helps develop and assess behavioral and pharmacological treatments of addiction; determines approaches to integrate these findings into clinical practice; and identifies policies that support integration. This program will be greatly enhanced by the prior training success of the program's 12 core faculty, who are MDs or PhDs with appointments in Pharmacology and Toxicology, Psychiatry, and Health Behavior and Health Promotion departments and have 22 NIDA, 3 N1AA, 1 N1CHD, 1 SAMSHA, 1 NIMH, and 16 VA research grants. Among the 28 predoctoral and 37 postdoctoral students trained by these core faculty, 86% of the predoctoral and 89% of postdoctoral students are still involved in research/academics and 49% of postdoctoral trainees have faculty positions. Collectively, trainees authored more than 500 publications were first author on 40% of them, and obtained 43 research grants. The new program proposed here will train, through stepped increases in enrollment, a total of 5 predoctorals, 7 postdoctorals, and 19 medical students by the end of the grant cycle. Trainee selection will be based on scholastic excellence and commitment to addiction research careers. Training will take place at the Center for Addiction Research. PUBLIC HEALTH RELEVANCE: This proposed training program is relevant to the public health because it will train new scientists at the pre and post doctoral level to conduct translational research into addictions and its treatment.