CHEMICAL SYNTHESIS CORE FACILITY

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 化学合成核心设施由Robert Gawley指导，他是一位新的高级教员，在合成有机化学和天然产物化学方面拥有丰富的经验，涉及倍半萜烯，树枝状聚合物，海洋毒素和化学传感器等分子。 COBRE中心正在努力探索小分子与蛋白质的相互作用，这种相互作用是绝大多数药物作用的原因。这些努力需要在有机合成的小分子的制备，以及在评估的小分子与感兴趣的蛋白质的相互作用的专业知识。 合成核心设施中的设备包括八台拉德利12容器平行合成器、一台CEM Explorer自动微波合成工作站、一台Agilent GC-MS以及Bruker Avance 300和400 MHz NMR光谱仪。 在核心设备的638，174美元费用中，40，000美元由COBRE赠款提供，其余来自其他赠款和机构资金。 Kwangyul Moon博士是一位经验丰富的合成有机化学家，负责核心中制备的化合物的合成和质量控制。 该大学已承诺机构资金，以支持马文莱斯特，杰里霍姆斯利和K.Z.的永久工作人员职位。他负责维护堆芯的仪器。 该大学还承诺购买一台新的小分子X射线衍射仪，用于确定核心中合成的分子结构。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Chemical Synthesis Core Facility is directed by Robert Gawley, a new senior faculty member with extensive experience in synthetic organic chemistry and natural products chemistry, involving molecules such as sesquiterpenes, dendrimers, marine toxins, and chemosensors. A significant effort is being made in the COBRE Center to probe the interaction of small molecules with proteins, interactions which are responsible for the action of the vast majority of pharmaceuticals. These efforts require expertise in organic synthesis for the preparation of the small molecules, as well as in evaluating the interactions of the small molecules with proteins of interest. Equipment in the Synthesis Core facility includes eight Radley 12-vessel parallel synthesizers, a CEM Explorer Automated Microwave Synthesis Workstation, an Agilent GC-MS, and Bruker Avance 300 and 400 MHz NMR spectrometers. Of the $638,174 cost of the equipment in the core, $40,000 was provided by the COBRE grant, with the remainder coming from other grants and institutional funding. Dr Kwangyul Moon, an experienced synthetic organic chemist, is responsible for the synthesis and quality control of the compounds prepared in the core. The University has committed institutional funds to support permanent staff positions for Marvin Leister, Jerry Homesley, and K.Z. Shein, who maintain the instrumentation in the core. The University is also committing $210,000 for the purchase of a new small molecule X-ray diffractometer, which is needed to determine the structures of the molecules synthesized in the core.