Design, Methods, Biostatistics, and Economic Analysis Core

设计、方法、生物统计和经济分析核心将为CEBP项目调查人员和其他CUMC自我管理调查人员提供建议、培训和帮助。服务请求和服务请求的履行情况将通过CTSA工作网站进行跟踪，如评估计划中所述。 发展和评价服务的时间表也包括在评价计划中。 核心专家将就研究过程的各个方面向自我管理调查人员提供建议，包括：选择研究设计、匹配目标和研究设计、为自我管理干预创建适当的对照小组、扩大战略以最大限度地提高服务不足人群的参与，以及选择分析战略。此外，他们还将向CEBP项目调查人员(Aboelela、Capili、Currie、SMalone)提供建议，说明如何最大限度地利用从他们的项目中学到的东西，作为未来R01提交的初步研究。 培训的主要方法将是：1)自我管理的跨学科方法研究研讨会；2)参考哥伦比亚大学现有的教育方案；3)经济评估讲习班。 自我管理的跨学科方法研究研讨会每年由20个一小时的课程组成，分成不同的核心。每年将有五次会议专门讨论与设计、方法、生物统计学和经济分析核心相关的主题。贾博士将就选定的统计主题进行一系列讲座，如功率分析、抽样技术和时间分析。阿纳斯塔西博士会 讨论服务不足人群的研究参与者的外展主题，以及在为自我管理干预试验设计适当的对照小组时应考虑的因素。此外，阿纳斯塔西博士和贾博士将介绍项目调查人员和其他自我管理调查人员参加哥伦比亚大学校区的相关培训，包括贾博士在生物统计学系教授的课程。 正如在提交本文件时所述，需要研究自我管理对个人、对其周围的人以及对整个社会的经济影响。因此，我们提交的文件包括明确为满足这一需要而设计的目标。实现这一目标的一个关键组成部分是熟悉自我管理的干部 进行经济评估的调查人员。斯通博士将与外部顾问委员会成员Kevin Frick博士协商，开发一系列研讨会，在有空间的基础上为CEBP项目调查员和其他CUMC自我管理调查员提供经济评估方面的知识和技能。因为高质量的严格经济评估可能很复杂，而且需要时间来获得 掌握，目标不是发展调查人员成为独立的经济研究人员，而是使新的自我管理调查人员熟悉经济术语、经济分析的类型和可用的资源，以便他们可以有效地：1)制定适当的具体目标 关于资源利用、生活质量和/或成本效益，以及2)聘请其他适当的跨学科专家作为合作者。将利用大学内部的资源和专家以及各国的专门知识。 CEBP项目的所有调查员都将参加经济分析讲习班。在第一年，将举办四个两小时的讲习班，讨论以下主题：1)经济评价概览(2节)；2)经济评价资源；3)批评经济评价。在第二年，项目调查员将 在斯通博士的指导下，制定与其特定项目相关的经济目标，选择适当的经济方法来实现目标，并在咨询跨学科专家的情况下制定分析计划。我们将在第三年和第四年重复这一系列。希望获得更多经济分析培训的调查人员将被推荐到哥伦比亚校园的研讨会和课程，如P8541： 高级经济学：技术评估和经济评估。他们可以注册这样的课程，免学费作为教职员工的福利。 除咨询和培训活动外，核心专家和其他CEBP人员还将协助CEBP项目调查员和其他自我管理调查员完成以下任务：设计分析计划、权力分析、选择适当的统计软件、数据管理战略以及编码簿开发和数据录入(由行政核心资助的研究生研究助理)。

The Design, Methods, Biostatistics, and Economic Analysis Core will provide advice, training, and assistance to CEBP project investigators and other CUMC self-management investigators. Service requests and fulfillment of service requests will be tracked through the CTSA WorkWeb as described in the Evaluation Plan. The timeline for development and evaluation of services is also included in the Evaluation Plan. Core experts will advise self-management investigators on various aspects of the research process including: selection of a research design, matching aims and research design, creating an appropriate control group for a self-management intervention, outreach strategies to maximize participation from underserved populations, and selecting analytic strategy. In addition, they will advise CEBP project investigators (Aboelela, Capili, Currie, Smaldone) on how to maximize what is learned from their projects as preliminary studies for future R01 submissions. The primary approaches for training will be: 1) the Interdisciplinary Methods for Self-Management Research Seminar; 2) referrals to existing educational offerings at Columbia; and 3) economic evaluation workshops. The Interdisciplinary Methods for Self-management Research Seminar comprises 20 one hour sessions per year to be divided among Cores. Five sessions each year will be devoted to topics related to the Design, Methods, Biostatistics, and Economic Analysis Core. Dr. Jia will provide a series of lectures on selected statistical topics such as power analysis, sampling techniques, and temporal analyses. Dr. Anastasi will address the topics of outreach for research participants from underserved populations and considerations in designing an appropriate control group for self-management intervention trials. In addition, Dr. Anastasi and Dr. Jia will refer project investigators and other self-management investigators to relevant training on the Columbia campus including the course that Dr. Jia teaches in the Department of Biostatistics. As noted in the RFA for this submission, research is needed on the economic effects of self-management for the individual, for those around them, and for society at large. Consequently, our submission includes an aim explicitly designed to meet this need. A key component for achieving this aim is familiarizing a cadre of selfmanagement investigators with economic evaluations. Dr. Stone in consultation with External Advisory Board member Kevin Frick, PhD will develop a series of workshops to provide CEBP project investigators and other CUMC self-management investigators on a space-available basis with knowledge and skills in economic evaluation. Because high quality rigorous economic evaluations can be complex and it takes time to gain mastery, the goal will not be to develop the investigators to become independent economic researchers, but rather to familiarize the new self-management investigators with the economic terminology, types of economic analyses and the resources available to them so they may effectively: 1) develop appropriate specific aims regarding resource utilization, quality of life and/or cost-effectiveness and 2) engage other appropriate interdisciplinary experts as collaborators. Resources and experts internal to the University as well as national expertise will be used. All CEBP project investigators will participate in the economic analysis workshops. In Year 1, four 2-hour workshops will be held on the following topics: 1) overview of economic evaluations (2 sessions); 2) resources for economic evaluations; and 3) critiquing economic evaluations. In Year 2, the project investigators will develop an economic aim of relevance to their particular project, select the appropriate economic method to achieve the aim and under Dr. Stone's direction, and construct an analytic plan in consultation with an interdisciplinary expert. We will repeat this series in Years 3 and 4. Investigators wishing additional training in economic analysis will be referred to workshops and courses on the Columbia campus such as P8541: Advanced Economics: Technology Assessment and Economic Evaluation. They may register for such offerings tuition-free as a faculty benefit. In addition to advising and training activities, Core experts and other CEBP personnel will assist CEBP project investigators and other self-management investigators with tasks such as design of analytic plans, power analysis, selection of appropriate statistical software, data management strategies, and code book development and data entry (Graduate Research Assistant funded in Administrative Core).