THERAPEUTIC EFFECTS AND ABUSE OF GABA(A) MODULATORS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 苯二氮类药物(BZS)被广泛用作抗焦虑药、催眠药、肌肉松弛药和抗惊厥药。尽管BZS被认为是现代医学中最安全的处方药之一，但它们的用途受到许多副作用的限制，包括不想要的镇静、运动能力受损和上瘾的可能性。该项目旨在确定BZ类药物临床有益与不良副作用背后的GABA(A)受体亚型机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Benzodiazepines (BZs) are prescribed widely as anxiolytics, hypnotics, muscle relaxants, and anticonvulsants. Although BZs are considered to be among the safest prescription drugs in modem medicine, their utility is constrained by a number of side effects, including unwanted sedation, impaired motor performance, and the liability for addiction. This project seeks to identify the GABA(A) receptor subtype mechanisms underlying the clinically beneficial vs. unwanted side effects of BZ-type drugs.