CART PEPTIDES IN AROUSAL AND SLEEP

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 由于初步研究表明，将CART多肽注射到大脑中会阻止睡眠，因此需要对这种影响进行更详细的研究。相应地，给大鼠注射CART多肽，并进行睡眠电生理测量。清醒程度通过睡眠图进行量化。 侧脑室注射CART 55-102对觉醒的促进作用较强，注射后持续4h。这些发现指出了CART在调节清醒方面的一个潜在的新角色。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Because of preliminary studies that showed that injection of CART peptide into the brain prevented sleep, a more detailed study of this effect was needed. Accordingly, rats were injected with CART peptide and sleep was measured electrophysiologically. Wakefulness was quantified from the somnogram. The effect of icv injection of CART 55-102 on promoting wakefulness was robust and lasted for up for 4 hours following injection. These findings point to a potential novel role for CART in regulating wakefulness.