PHYSIOLOGY AND PATHOPHYSIOLOGY OF BASAL GANGLIA IN PARKINSON?S DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：利用恒河猴帕金森病和脑深部刺激(DBS)模型，探讨基底神经节和运动、感觉皮质作为一个功能单位的作用。发展和改进硬膜外运动皮质刺激治疗运动障碍的方法。发展和推进基底节-丘脑-皮质系统的计算模型和DBS的影响。 实验室功能齐全。我们已经开发了用于数据指控和分析的新技术和方法。猕猴基底神经节-丘脑-皮质系统的微电极记录。本研究使用了WNPRC动物服务和WNPRC运营服务(Shop)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To use rhesus monkey (Macaca mulatta) models of Parkinsonism and deep brain stimulation (DBS) as a way to probe how the basal ganglia and the motor and sensory cortex act as a functioning unit. To develop and advance the methods of Epidural Motor Cortex Stimulation for movement disorders. Develop and advance computational modeling of the basal ganglia-thalamic-cortical system and the effects of DBS. The laboratory is fully functional. We have developed new technologies and methodologies for data accusation and analysis. Microelectrode recordings in the basal ganglia-thalamic-cortical system in a behaving rhesus monkey. This research used WNPRC Animal Services and WNPRC Operational Services (Shop).