A PRIMATE MODEL OF GUT, IMMUNE, AND CNS RESPONSE TO CHILDHOOD VACCINES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 20世纪90年代，对接受疾病控制中心(CDC)推荐的完整儿童疫苗方案的婴儿恒河猴进行了一项试点项目。结果表明，接种疫苗的猴子表现出行为障碍和胃肠道炎症，具有类似克罗恩病的特征。这项后续研究还将对恒河猴婴儿进行研究，以确定这些不良后果是否与只含有防腐剂、含有活病毒或两者兼有的人类腮腺炎措施风疹疫苗有关。第一项研究的目的是更全面地检查这些疫苗组合对婴儿行为、认知以及大脑结构和化学方面的发育影响。第二个目标是确定胃肠道炎症是否再次与疫苗条件有关，如果是的话，受影响的动物是否也表现出发育障碍。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A pilot project was performed studying infant rhesus macaques who received the complete childhood vaccine regimen recommended by the Center for Disease Control (CDC) through the 1990s. The results demonstrated that vaccinated monkeys displayed behavioral impairments and exhibited gastrointestinal inflammation with features similar to Crohn's disease. This followup research will also study rhesus macaque infants to determine whether these adverse outcomes are associated with human mumps-measels-rubella vaccines that only contain preservatives, that contain live-viruses, or contain a combination of both. The first study aim is to more fully examine the developmental effects of these vaccine combinations on infant behavior, cognition, and aspects of brain structure and chemistry. The second aim is to determine if gastrointestinal inflammation is again related to vaccine condition, and if so whether afflicted animals also display developmental impairments.