USE OF AN ORGANOPHOSPHORUS (OP) HYDROLASE FOR ACUTE OP TOXICITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这笔赠款的目的是测试一种新型有机磷农药降解酶OpdA在该NHP模型中的安全性和有效性。证明这种酶对对硫磷是安全有效的，应该为进一步开发人类使用提供必要的动力。我们的中心假设是OpdA是安全的，可以提高对硫磷中毒后的存活率。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purposes of this grant is and to test the safety and efficacy of a novel organophosphorus pesticide degrading enzyme, OpdA, in this NHP model. Proof that the enzyme is safe and effective against parathion should provide the necessary impetus for further development for human use. Our central hypothesis is that OpdA is safe and improves survival after poisoning with parathion.