SACCADE STUDIES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们工作的最终目标是了解大脑是如何运作的。为了做到这一点，我们研究了输出(马达)部分，使用动眼系统作为模型。具体地说，我们研究的是那些被称为眼跳运动的快速运动。我们继续研究眼跳产生的机制，最近重点研究了尾侧小脑顶核(CFN)的功能。这些研究代表了我们的新方向，而且仍处于早期阶段，因此本财年没有新的出版物。它们包括3个相关的调查，以测试CFN是否对正常眼跳的产生是必要的。我们的预期结果将从根本上改变我们认为的眼跳产生的方式。它们不仅将提高我们对眼球运动过程的理解，还可能为小脑功能提供一个新的模型。它们不仅将促进我们对大脑如何处理信息以便根据这些信息制定行动的理解，而且它们也是目前临床上常用的基于眼球运动体征的鉴别神经学诊断的基础。它们还为研究中枢神经系统功能的更复杂方面提供了基础，例如运动系统(例如，定向时的眼睛和头部)或感觉和运动系统(例如，视觉和眼动系统)之间的相互作用，以及更抽象的功能，如注意力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The ultimate goal of our work is to understand how the brain functions. To do this, we study the output (motor) portions, using the oculomotor system as a model. Specifically we study those fast movements known as saccadic eye movements. We continue our studies of mechanisms of saccade generation and have recently focused on the function of the caudal Fastigial nucleus (cFN). These studies represent a new direction for us and are still in early stages so no new publications have resulted in the current fiscal year. They consist of 3 related investigations to test whether the cFN is essential to the production of normal saccades. Our anticipated results will change fundamentally the way that we think saccades are produced. Not only will they improve our understanding of oculomotor processes but they may provide a new model for cerebellar function.They will not only advance our understanding of how the brain processes information in order to formulate actions based on that information, but they are also basic to the differential neurological diagnosis based on eye-movement signs now commonly used clinically. They also provide a foundation for studies of more complex aspects of central nervous system function such as interactions between motor systems (e.g., eye and head during orientation) or sensory and motor systems (e.g., the visual and oculomotor systems) and more abstract functions such as attention.