FLOW EFFECTS OF ENDOTHELIAL/TROPHOBLAST INTERACTION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的目标是： 1)FSS诱导的滋养层细胞整合素β1表达上调和内皮细胞迁移是否依赖于ErbB介导的MUC1的磷酸化？ 2)FSS介导的滋养层细胞整合素β1表达上调和迁移活性是否需要MUC1和ER之间的直接相互作用？ 3)FSS诱导的滋养层细胞整合素β1表达上调和迁移活性是否依赖于MUC1介导的ERs的磷酸化？ 4)在FSS条件下，MUC1是否通过调节ER的细胞内定位来调节ER的功能？ 5)确定MUC1是否对直接施加的力做出响应

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objectives of this project are: 1) Does FSS-induced upregulation of trophoblast ¿1 integrin expression and cell migration on endothelium depend on ErbB-mediated phosphorylation of MUC1? 2) Does FSS-mediated upregulation of trophoblast ¿1 integrin expression and migratory activity require direct interaction between MUC1 and ERs? 3) Does FSS-induced upregulation of trophoblast ¿1 integrin expression and migratory activity depend on MUC1-mediated phosphorylation of ERs? 4) Does MUC1 modulate ER function under FSS conditions by regulating the intracellular localization of ERs? 5) Determine whether MUC1 responds to directly applied force