Hollow Fiber Production of Monoclonal Antibodies

中空纤维MAB的生产利用纤维单元系统模块和 一种专用泵，用于迫使液体介质通过一束半渗透纤维。高度 浓缩的MAB保留在腔室中，并直接从纤维中利用，或 根据研究者的需要进一步处理。特殊的无蛋白培养基是 如果MAB直接用于动物，则使用。标准组织产生的抗体 培养技术使用塑料瓶和标准培养基。在2008财年， 生长，产生近30克抗体。（草案）

The production of hollow fiber MABs utilizes a Fiber Cell System module and a specialized pump to force liquid media through a bundle of semi-permeable fibers. Highly concentrated MAB is retained in the chamber and is utilized directly from the fiber or processed further depending on the needs of the investigator. Special protein free media is used if the MAB is to be used directly in animals. Antibodies produced by standard tissue culture techniques utilize plastic flasks and standard media. During FY08 8 MABs have been grown, producing nearly 30g of antibody. (DRAFT)