Training Program in Cellular, Biochemical, and Molecular Sciences

描述(由申请人提供)：本申请请求支持托马斯·杰斐逊大学细胞、生化和分子科学的博士前培训计划。该课程为学生提供广泛的多学科训练，使用生化、细胞和分子策略解决重要的生物学问题。该项目的所有导师都建立了研究计划，并在指导方面拥有丰富的经验。具体培训领域包括生长因子、G蛋白偶联和核受体信号、信号整合、蛋白质靶向和运输、细胞周期调节、细胞凋亡、 转录和DNA修复。正在进行的研究项目涉及这些领域对正常运作以及疾病进程和治疗发明的重要性。此外，相当多的导师在他们的研究中使用动物模型和翻译方法。这一独特的参与教员组合将通过课程作业、直接指导互动、专业教育活动、研讨会和半年一次的务虚会提供培训。细胞、生化和分子科学的培训计划包括来自7个基础和临床科室的25名导师，由首席调查员和管理委员会管理。领导团队的重点是向不同种族和不同科学背景的受训干部提供卓越的培训。该计划将通过内部和外部审查机制进行评估，以确保受训人员获得尽可能好的培训体验。总体而言，该计划将为学员提供出色的职业发展，使他们能够从事依赖于如何使用机械方法解决重要科学问题的职业，并将提供关键的团队教育经验，了解使用动物模型和翻译方法了解疾病的多学科性质。 公共卫生相关性：该培训计划的总体目标是培养训练有素的研究科学家，他们了解如何解决重要的科学问题，并准备从事独立调查人员的职业生涯。该计划还为学员提供了对涉及健康和疾病的机制的了解，使我们的培训计划与公共卫生高度相关。

DESCRIPTION (provided by applicant): This application requests support for a predoctoral Training Program in Cellular, Biochemical and Molecular Sciences at Thomas Jefferson University. This Program provides students with broad multidisciplinary training in using biochemical, cellular and molecular strategies to address important biological questions. All mentors in this program have established research programs and significant experience in mentoring. Specific training areas include growth factor, G protein-coupled and nuclear receptor signaling, signal integration, protein targeting and trafficking, cell cycle regulation, apoptosis, transcription and DNA repair. Ongoing research projects address the importance of these areas to normal functioning as well as to disease processes and therapeutic inventions. In addition, a significant number of the mentors use animal models and translational approaches in their research. This unique combination of participating faculty will provide training through course work, direct mentoring interactions, specialized educational activities, seminars and semi-annual retreats. The Training Program in Cellular, Biochemical and Molecular Sciences includes 25 mentors from 7 basic and clinical departments and is administered by the Principal Investigator and Administrative Committees. The leadership team is focused on delivering training excellence to an ethnically and scientifically diverse cadre of trainees. The program will be evaluated through both internal and external review mechanisms to ensure that the trainees are receiving the best possible training experience. Overall, this Program will provide outstanding career development for trainees to pursue careers dependent on knowing how to use mechanistic approaches to address important scientific questions and it will provide a critical team educational experience in the multidisciplinary nature of using animal models and translational approaches to understand disease. PUBLIC HEALTH RELEVANCE: The overall goal of this training program is to develop highly trained research scientists who understand how to address important scientific questions and are ready to pursue careers as independent investigators. The program also provides trainees with an understanding of the mechanisms involved in health and disease, giving our training program high relevance to public health.