Development of Trans Proteomics Pipeline, an Analysis Suite for Mass Spectrometry

描述（由申请人提供）：Trans-Proteomic Pipeline （TPP）是一套完整、免费且被广泛采用的工具，用于分析串联质谱（MS/MS）蛋白质组学数据（“shotgun proteomics”）。TPP用于分析原始的质谱/质谱数据，以确定和量化蛋白质及其在细胞和组织中的丰度水平，从而调查围绕疾病原因识别、诊断技术生产和治疗方法开发的研究问题。TPP已经被数百名研究人员使用，对许多正在进行的研究项目至关重要。这笔拨款将使我们能够继续保持当前的功能，支持社区，并适应不断变化的蛋白质组学技术和技术。

DESCRIPTION (provided by applicant): The Trans-Proteomic Pipeline (TPP) is a complete, free, and widely-adopted suite of tools for the analysis of tandem mass spectrometry (MS/MS) proteomics data ("shotgun proteomics"). The TPP is used for analyzing raw MS/MS data to identify and quantify proteins and their abundance levels in cells and tissues, allowing investigation of research questions surrounding the identification of causes of disease, the production of diagnostic techniques, and the development of treatments. The TPP is already in use by a community of hundreds of researchers, and is of fundamental importance to many ongoing research projects. This grant will allow us to continue to maintain current functionality, support the community, and adapt to changing proteomics technology and techniques. PUBLIC HEALTH RELEVANCE: Mass spectrometry based proteomics has become key to the study of many aspects of human health, it allows for the study of disease pathology, the identification of diagnostic markers and the development of treatments. The Trans Proteomics Pipeline software suite has become the cornerstone for numerous research groups who undertake mass spectrometry based experiments. This grant will enable the maintenance and evolution of this invaluable software, and enable its continued usage and expansion of its relevance throughout research institutions, hospitals, university departments and commercial organizations.