Bioinformatics Core Facility

生物信息学对任何癌症中心来说都是至关重要的，使研究人员能够利用不断增长的数据集 由新的癌症研究技术提供。无论如何令人生畏的海量数据集正在被创建， 必须进行分析，并需要与跨区域和临床终点相关。LCCC在这方面的专业知识 Area从基因组学计划开始，特别是基因表达微阵列分析。在必要的时候， 通过内部和外部建立了人员、计算机基础设施和广泛的教师专业知识 招聘。在过去三年中，功能迅速扩展以捕获临床数据和注释 标本。创建Lineberger数据仓库(LDW)是为了允许交互使用多个Oracle 基于数据存储库。随着工作人员和任务的扩大，基因组学和生物信息学被分开了 分成两种资源。生物信息学、生物统计学和数据管理的关系， 基因组学和新的下一代基因分型核心将是无缝的。 生物信息核心的目标是局限于提供生物信息工具、用于存储和 分析基因组数据，用于临床/临床数据的存储和分析，并提供链接工具 这些定义数据类型共同促进了翻译研究的发现。新的恩菲亚公司， 例如癌症生存队列，正在发生。关键要素仍然是生物信息核心 中央患者登记处，在分配唯一的研究标识符后提供和跟踪所有患者。 该团队在基因组数据库开发和整理、基因组数据 分析和工具开发，临床数据库开发，并通过LDW将这些联系在一起。 核心将扩大能力，包括新的基因组图谱和新的临床数据库/肿瘤类型。 核心要求270,568美元，占其总运营成本的13%，以实现其雄心勃勃的目标。 2009年的所有核心用途都是由成员使用。联合主任佩鲁博士和海斯博士是基因组学领域的领导者。 分析及其与临床终点的整合。

Bioinformatics is critical for any cancer center, allowing researchers to tap the ever-growing data sets afforded by new cancer research technologies. However daunting, massive data sets are being created, must be analyzed, and need to be related to translafional and clinical end points. LCCC expertise in this area began with the genomics program, particularly gene expression microarray analysis. By necessity, the personnel, computafional infrastructure, and broad faculty expertise was built through internal and external recruitment. In the last three years, capabilifies rapidly expanded to capture clinical data and annotate specimens. The Lineberger Data Warehouse (LDW) was created to allow Interactive use of mulfiple oracle based data repositories. With this expanded staff and mission, the genomics and bioinformatics were divided into two resources. The relafionships between the Bioinformatics, Biostatisfics and Data Management, Genomics and the new Next Generafion and Genotyping Core will be seamless. The Bioinformafic Core's goals are to confinue to provide bioinformafics tools, databases for the storage and analysis of genomic data, for the storage and analysis of clinical/pafient data, and to provide tools to link these disfinct data types together to foster translational research discoveries. Incorporafion of new enfifies, such as the Cancer Survivorship Cohort, is occurring. The key element remains the Bioinformafics Core Central Patient Registry which provides and tracks all pafients after assigning a unique research identifier. The group has significant experience with genomic database development and curation, genomic data analysis and tool development, clinical database development, and linking these together through the LDW. The core will expand capabilifies to include new genomic plafi'orms and new clinical databases/tumor types. The core requests $270,568, representing 13% of its total operating costs to accomplish its ambitious goals. All core use in 2009 was by members. The co-directors, Drs. Perou and Hayes, are leaders in genomic analysis and its integration with clinical endpoints.