Administrative Core

夸大的心血管风险可以说是肾脏病学家和他们的患者面临的最紧迫的临床问题。肾病患者心血管疾病占优势的原因尚不清楚，但无论主要原因如何，高血压都会增加心血管风险并促进慢性肾病的进展。因此，乔治M.杜克大学的奥布莱恩肾脏研究核心中心旨在促进和支持了解肾脏、心血管疾病和高血压之间独特联系的研究。行政核心将负责中心的总体行政监督。主任托马斯科夫曼博士将主要负责协调日常业务。他将由副主任和中心管理员协助。该中心的主要管理将由一个执行委员会提供，该委员会由中心主任、副主任、核心主任、试点和可行性方案主席以及浓缩方案协调员组成。管理核心的具体目标是：（1）对核心业务和绩效进行全面监督;（2）审查并优先考虑使用核心服务的提案，包括：（a）确定研究者资格，（B）确定科学优先事项，以及（c）确定使用核心服务的总体优先事项;（3）根据新技术或服务的发展、现有技术或服务的次优性能和/或经济因素对核心服务进行修改;（4）促进核心之间的互动，重点是将发现从基础发现项目过渡到临床和转化项目，（5）评估资源分配的充分性;（6）监督试点和可行性研究，以探索与心血管疾病中的肾脏相关的新研究领域，作为其他外部资金的基础。这些资金将用于支持新的研究人员，并将用于吸引高级研究人员解决这一主题领域的关键问题;（7）制定旨在强调肾脏和心血管疾病相互关系的重要性的教育计划，告知中心研究人员相关研究的最新进展，并培训研究人员采用临床和基础科学方法推进研究。

Exaggerated cardiovascular risk is arguably the most pressing clinical problem facing nephrologists and their patients. The causes of this preponderance of cardiovascular disease in patients with kidney disease are not clear, but hypertension amplifies cardiovascular risk and promotes progression of chronic kidney disease irrespective of the primary cause. Accordingly, the major objective of the George M. O'Brien Kidney Research Core Center at Duke is to promote and support research into understanding the unique links between the kidney, cardiovascular disease, and hypertension. The Administrative Core will be responsible for the overall administrative oversight for the Center. The Director, Dr. Thomas Coffman, will have primary responsibility for coordinating day-to-day operations. He will be assisted by the Associate Director and Center Administrator. Primary governance of the Center will be provided by an Executive Committee consisting of the Center Director, Associate Director, the Core Directors, Chair of the Pilot and Feasibility Program, and Coordinator of the Enrichment Program. The Specific Aims of the Administrative Core are: (1) Provide general oversight of Core operations and performance; (2) Review and assign priorities to proposals for use of Core services, including: (a) establishing investigator eligibility, (b) determining scientific priorities, and (c) determining overall priorities for use of Core services; (3) Implement modifications in Core services based on development of new technologies or services, sub-optimal performance of existing technologies or services, and/or economic factors; (4) Promote interactions between the cores with an emphasis on transitioning discoveries from basic discovery projects to clinical and translational programs, (5) Assessing adequacy of resource allocation; (6) Oversight for pilot and feasibility studies to explore new areas of research relevant to the kidney in cardiovascular diseases serving as a foundation for other external funding. These funds will support new investigators, and will be used to entice senior investigators to address key issues in this thematic area; and (7) Develop education programs designed to highlight the importance of the interrelationship of kidney and cardiovascular disease, to inform Center investigators of the latest advances in relevant research, and to train investigators in clinical and basic science approaches to advance research.