Monitoring of leucocyte cytokine-chemokines to improve morbidity and rejection rates in lung transplant patients

肺移植已成为许多严重肺部疾病的公认治疗方法。现在早期成功率很高，但移植后五年的存活率只有60%左右。这个问题在很大程度上是由于慢性排斥反应或闭塞性细支气管炎综合征导致的慢性移植物失败。这个项目将专门调查BOS的原因，从而为我们如何最好地处理这个问题提供新的信息。这一领域的改善是至关重要的。

Lung transplantation has become established therapy for many serious lung diseases. The early success rate is now very good, but at five years after transplant the survival rate is only around 60%. This problem is largely due to chronic graft failue as a result of chronic rejection or bronchiolitis obliterans syndrome. This project will specifically investigate the causes of BOS and thereby provide new information on how we may best treat this problem. An improvement in this area is critical.