RESBIO - the Technology Resource for Polymeric Biomaterials

描述（由申请人提供）：高分子生物材料资源- RESBIO -将生物材料发现的新工程方法与最先进的细胞生物学和计算建模研究相结合。通过这种独特的学科组合，RESBIO有助于定量（而不是定性）理解细胞-物质相互作用，从而加速发现具有特定医疗应用优化性能的高分子生物材料。RESBIO的研究影响着生物材料科学、组织工程和再生医学领域，以及新型医疗植入物和药物输送系统的开发。在其第一个资助期内，RESBIO为开发一种新的疝气修复装置（通过FDA批准）和一种新的心血管支架（预计在不久的将来进入临床试验）做出了贡献。在下一个资助期内，RESBIO将扩大其研发核心研究项目的新方向，从定性研究向定量研究迈进；（ii）从2D（平面）测试系统推进到3D模型系统，用于研究细胞-物质相互作用；（三）结合作用于细胞和组织的机械力的研究。

DESCRIPTION (provided by applicant): The Resource for Polymeric Biomaterials - RESBIO - integrates a new engineering approach to biomaterials discovery with state-of-the-art research in cell biology and computational modeling. Through this unique combination of disciplines, RESBIO contributes to a quantitative (rather than qualitative) understanding of cell-material interactions leading to the accelerated discovery of polymeric biomaterials with optimized properties for specific medical applications. RESBIO's research impacts the fields of biomaterials science, tissue engineering and regenerative medicine as well as the development of new medical implants and drug delivery systems. During its first funding period, RESBIO contributed to the development of a new hernia repair device (approved by FDA) and a new cardiovascular stent (expected to enter into clinical trials in the near future). In the next funding period, RESBIO will expand its R&D Core research program into new directions by (i) progressing from qualitative to quantitative characterization studies; (ii) advancing from 2D (flat) test systems to 3D model systems for the study of cell-material interactions; and (iii) incorporating the investigation of mechanical forces acting on cells and tissues. RESBIO will develop "technology packages" that can be disseminated to and incorporated into the research activities of other laboratories through service, training and broad dissemination efforts. Core faculty are drawn from five institutions: Rutgers, the State University of New Jersey, University of Pennsylvania, Clemson University, University of Cambridge, UK and the National Institute of Standards and Technology. Seven proposed collaborative projects, diverse service interactions, and eight strategic alignments with major national research programs will strengthen RESBIO's impact on the field of biomaterials science.