An integrated startle response, fear conditioning, and muscle tremor analysis system for rodents

VA新泽西卫生保健系统（VANJHCS）正在申请资金购买 一种用于啮齿动物的替代惊吓/肌肉震颤系统。十八年后， 以前的定制系统已经年久失修，关键的更换部件 不再供应。由圣地亚哥开发和生产的SR-Lab系统 仪器被认为是测量啮齿动物声惊吓的目标-标准 反应和惊吓反射的前脉冲抑制。这些是评估技术 历史上被东橙子VA医学中心（EOVAMC）的研究人员用来 研究应激对惊吓反应的影响（作为创伤后应激模型 疾病，PTSD）。此外，来自EOVAMC研究人员的最新证据表明， 在脑外伤后，惊吓反应会在很长一段时间内受到抑制， 创伤（TBI）。EOVAMC的两个主要用户和两个次要用户需要SR-Lab 系统，以进一步他们在创伤后应激障碍和创伤性脑损伤领域的工作。两个主要用户 需要SR-Lab系统进行肌肉震颤的行为评估， 帕金森病（PD）的啮齿动物模型。总之，该系统将提供 确定VANJHCS的用户，需要完善措施和额外措施， 在没有以前的系统的情况下，适当地执行其资助的项目。

The VA New Jersey Health Care System (VANJHCS) is requesting the funds to purchase a replacement startle/muscle tremor system for rodents. After eighteen years, the previous custom-made system has fallen upon disrepair and key replacement parts are no longer supplied. The SR-Lab System developed and produced by San Diego Instruments is considered the goal-standard for measuring the rodent acoustic startle response and pre-pulse inhibition of the startle reflex. These are assessment techniques historically used by the researchers at the East Orange VA Medical Center (EOVAMC) to study the effects of stress on startle reactivity (as a model of post-traumatic stress disorder, PTSD). In addition, recent evidence from EOVAMC researchers suggest that the startle response is dampened for long periods of time following traumatic brain injury (TBI). Two major users and two minor users at the EOVAMC require the SR-Lab System to further their work in the areas of PTSD and TBI. Two additional major users require the SR-Lab System for behavioral assessments of muscle tremors for their rodent models of Parkinson's Disease (PD). In all, this system would provide the identified users at VANJHCS with refined measures and additional measures needed to properly execute their funded projects in the absence of the previous system.