Investigating the unification of supramolecular and organometallic catalysis for new reaction development

表现出良好反应活性的有机金属催化剂的发展 同时在相似官能团之间提供化学选择性往往与一个 又一个。这些挑战在制备具有生物重要性的分子或 修改现有支架以研究结构活性关系，如下所示 高价值底物通常含有具有交叉反应性的官能团。有能力 开发能够进行精确修饰的催化剂仍然是一个备受追捧的目标 学术和工业研究。这些协议的演示代表着 新一代生物相关化合物的催化剂设计和合成 具有拯救生命的性能。这份提案概述了一种将有机金属 用超分子团簇催化绕过交叉的固有问题 在络合物上实现化学选择性和最终的对映选择性转化 分子支架。超分子团簇已经证明有能力赋予独特的反应性 在有机和有机金属转化中，通过动态微环境 受益于大量的非共价相互作用。受这些成功的启发，这项研究 本建议书中概述的计划提供了两条从有希望的初始计划建立起来的途径 我收集到的结果。最终，对映体选择性转化的研究 将揭示超分子簇与有机金属的非共价相互作用 催化剂，为动态微环境如何影响催化提供了独特的观点。这个 拟议的研究最终寻求开发有助于准备的方法 以及以一种新的方式对结构复杂的药物相关分子进行修饰 随之而来的是扩展科学知识。

The development of organometallic catalysts that exhibit good reactivity while concurrently offering chemoselectivity between similar functional groups are often at odds with one another. These challenges culminate when preparing biologically important molecules or modifying existing scaffolds to investigate structure activity relationships as these high-value substrates often contain functional groups with cross reactivity. The ability to develop catalysts capable of performing precise modifications remains a highly sought after goal in academic and industrial research. Demonstration of these protocols represents a major triumph in catalyst design and synthesis which leads to the next generation of biologically relevant compounds with life-saving properties. This proposal outlines a strategy that combines organometallic catalysis with supramolecular clusters to circumnavigate the inherent issues of cross reactivity and achieve chemoselective and ultimately enantioselective transformation on complex molecular scaffolds. Supramolecular clusters have a demonstrated ability to endow unique reactivity in organic and organometallic transformations through a dynamic microenvironment that benefits from numerous non-covalent interactions. Inspired by these successes, the research program outlined in this proposal offers two paths which build from promising initial results I have gathered. Ultimately, the investigation of enantioselective transformation will reveal the non-covalent interactions of a supramolecular cluster and organometallic catalysts, yielding a unique view of how dynamic microenvironments influence catalysis. The proposed research ultimately seeks to develop methods that will facilitate the preparation and modification of structurally complex medicinally relevant molecules in a novel way concomitantly expanding scientific knowledge.