Vascular and Cardiac Function Core - "Mentoring in Cardiovascular Biology

血管和心脏功能核心将为Cobre和LSUHSC提供服务和培训 研究人员将使用心血管疾病的动物模型和/或体内技术来回答 在他们的项目中勾勒出的具体目标。这个核心的具体目标是：1.为 协助和/或执行涉及超声成像的高度专业化的外科和技术程序， 使用压力-体积电导导管对血压进行无线电遥测记录 心脏结构和功能，交感神经记录，显微注射程序，血管损伤， 心肌缺血和血流，以及肾功能的评估；2.协助制作模型 高血压，缺血/再灌注损伤，血管损伤，动脉粥样硬化，糖尿病，脑缺血，急性 肾损伤、容量超负荷和药物引起的心脏损伤，将从这些组织中收集组织用于 组织、生化、遗传和/或蛋白质组分析；3.进行实验并协助Cobre 和LSUHSC调查人员一起收集和解释生理数据；4.教育 关于血管和心脏功能核心资源的潜在用途的研究人员 他们的研究目标，并为发展翻译研究项目提供了途径。 调查人员将可以访问核心设施，以完成他们自己或与 核心技术人员的协助和监督。核心还将提供服务的设计和 为心血管研究开发新的动物模型。核心的服务包括：1) 超声成像，2)测量血压、心率、自发性压力反射和核心身体 无线电遥测的温度，3)血压和心率的尾袖分析，4)心脏左 脑室压力-容量分析，5)中枢神经系统微量注射，6)微透析，7)神经记录，8)组织 收集、血液流动分析、血液化学，以及评估肾脏水的排泄情况 还有电解液。由该核心提供的最先进的技术和经验丰富的人员将 加强科布雷和大学调查人员在获得外部资金方面的进展。

The Vascular and Cardiac Function Core will provide services and training for COBRE and LSUHSC investigators who will use animal models of cardiovascular disease and/or in vivo technology to answer specific aims outlined in their projects. The specific aims of this Core are: 1. To provide skilled personnel to assist and/or perform highly specialized surgical and technical procedures involving ultrasound imaging, radio telemetric recording of blood pressure, use of pressure-volume conductance catheters to assess cardiac structure and function, sympathetic nerve recording, microinjection procedures, vascular injury, cardiac ischemia and blood flow, and assessment of renal function; 2. To assist in producing models of hypertension, ischemia/reperfusion injury, vascular injury, atherosclerosis, diabetes, cerebral ischemia, acute kidney injury, volume overload and drug-induced cardiac damage from which tissues will be collected for histological, biochemical, genetic and/or proteomic analysis; 3. To conduct experiments and assist COBRE and LSUHSC investigators with the collection and interpretation of physiological data; 4. To educate investigators regarding potential uses of The Vascular and Cardiac Function Core resources to enhance their research objectives and provide avenues towards developing translational research projects. Investigators will have access to the core facilities to complete experimental protocols on their own or with the aid and supervision of the Core's technical staff. The core will also provide services for the design and development of new animal models for cardiovascular research. The services ofthe Core encompass; 1) ultrasound imaging, 2) measurement of blood pressure, heart rate, spontaneous baroreflex, and core body temperature by radio telemetry, 3) tail cuff analysis of blood pressure and heart rate, 4) cardiac left ventricular pressure-volume analysis, 5) CNS microinjection, 6) microdialysis, 7) nerve recording, 8) tissue collection, 9) blood flow analysis, 10) blood chemistry, and 11) assessment ofthe renal excretion of water and electrolytes. The state-of-the-art technology and experienced personnel provided by this Core will enhance the COBRE and University investigators progress towards acquisition of extramural funding.