COBRE: LSC HSC: CARDIAC & VASCULAR FUNCTION CORE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。心脏和血管功能核心负责在大鼠颈动脉和股动脉中产生球囊导管诱导的损伤。Chilian博士的实验室也正在开发一种球囊导管诱导的大鼠冠状动脉损伤模型，这可能对评估不同的血管床具有特殊价值。心血管功能评估的基础技术，包括遥测和体内超声成像，也是这一核心的核心。该核心还包含灌注心脏制备和离体血管研究的设置。该核心还可以产生冠状动脉疾病、血管生成、动脉生成、缺血预处理和再灌注损伤的动物模型。我们已经开始为卡特林和帕克博士在大鼠和兔子身上制造动脉损伤，并开始了血管损伤的时间过程研究。Millar电导导管系统的增加使我们能够在体内研究大鼠和小鼠的心脏功能。核心的一项主要服务是提供超声成像。我们已经为COBRE上的Park、Boulares和Wu博士以及LSUHSC和杜兰大学的许多其他实验室提供了这项服务。该核心产生的数据已导致若干摘要、赠款（已资助和待资助）和合同。还有几份手稿有待处理。在不久的将来，我们希望增加测量动脉血气的能力，并在清醒的啮齿动物中进行呼吸功能的研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Cardiac and Vascular Function Core is responsible for generating balloon catheter-induced injuries in the carotid and femoral arteries in rats. Dr. Chilian's laboratory is also developing a balloon-catheter-induced injury model of the rat coronary artery, which may prove of particular value for evaluating different vascular beds. Also centered in this core is basic technology for cardiovascular function assessment including telemetry and in vivo ultrasound imaging. This core also contains set-ups for perfused heart preparations and studies of isolated blood vessels. This core can also generate animal models of coronary artery disease, angiogenesis, arteriogenesis, ischemic preconditioning and reperfusion injury. We have already begun to make arterial injuries in rats and rabbits for Drs. Catling and Park and have begun time course studies of the vascular injuries. The addition of a Millar Conductance Catheter system has given us the ability to study cardiac function in rats and mice in vivo. A major service of the Core has been providing ultrasound imaging. We have provided this service to Drs. Park, Boulares and Wu on the COBRE and to many other laboratories at LSUHSC and Tulane University. The data generated by the Core has led to several abstracts, grants (funded and pending) and contracts. Several manuscripts are also pending. In the near future we hope to add the capability to measure arterial blood gases and to conduct studies of respiratory function in conscious rodents.