COBRE: LSC HSC: CARDIAC & VASCULAR FUNCTION CORE

COBRE：LSC HSC：心脏

• 批准号: 7382070
• 负责人: Kurt J. Varner
• 金额: $ 11.32万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7382070
• 关键词: COBRE; LSC; HSC; CARDIAC; VASCULAR

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Cardiac and Vascular Function Core is responsible for generating balloon catheter-induced injuries in the carotid and femoral arteries in rats. Dr. Chilian's laboratory is also developing a balloon-catheter-induced injury model of the rat coronary artery, which may prove of particular value for evaluating different vascular beds. Also centered in this core is basic technology for cardiovascular function assessment including telemetry and in vivo ultrasound imaging. This core also contains set-ups for perfused heart preparations and studies of isolated blood vessels. This core can also generate animal models of coronary artery disease, angiogenesis, arteriogenesis, ischemic preconditioning and reperfusion injury. We have already begun to make arterial injuries in rats and rabbits for Drs. Catling and Park and have begun time course studies of the vascular injuries. The addition of a Millar Conductance Catheter system has given us the ability to study cardiac function in rats and mice in vivo. A major service of the Core has been providing ultrasound imaging. We have provided this service to Drs. Park, Boulares and Wu on the COBRE and to many other laboratories at LSUHSC and Tulane University. The data generated by the Core has led to several abstracts, grants (funded and pending) and contracts. Several manuscripts are also pending. In the near future we hope to add the capability to measure arterial blood gases and to conduct studies of respiratory function in conscious rodents.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。心脏和血管功能核心负责在大鼠颈动脉和股动脉中产生球囊导管诱导的损伤。Chilian博士的实验室还在开发一种球囊导管诱导的大鼠冠状动脉损伤模型，这可能对评估不同的血管床具有特殊的价值。同样以这一核心为中心的是心血管功能评估的基础技术，包括遥测和体内超声成像。该核心还包含了灌注心脏准备和分离血管研究的设置。该核心还可以生成冠状动脉疾病、血管生成、动脉生成、缺血预处理和再灌注损伤的动物模型。我们已经开始在大鼠和兔子身上进行动脉损伤。Catling和Park已经开始了血管损伤的时间过程研究。米勒导管系统的加入使我们能够在体内研究大鼠和小鼠的心脏功能。核心中心的一项主要服务是提供超声成像。我们已经为博士提供了这项服务。Park， Boulares和Wu在COBRE以及LSUHSC和杜兰大学的许多其他实验室。核心项目产生的数据导致了一些摘要、拨款（已资助的和未决的）和合同。还有几份手稿尚未完成。在不久的将来，我们希望增加测量动脉血气的能力，并对有意识的啮齿动物的呼吸功能进行研究。