COBRE: LSC HSC: CARDIAC & VASCULAR FUNCTION CORE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Cardiac and Vascular Function Core is responsible for generating balloon catheter-induced injuries in the carotid and femoral arteries in rats. Also centered in this core is basic technology for cardiovascular function assessment including telemetry and in vivo ultrasound imaging. This core contains set-ups for perfused heart preparations and studies of isolated blood vessels. This core can also generate animal models of coronary artery disease, angiogenesis, arteriogenesis, ischemic preconditioning and reperfusion injury. We have developed an areterial injury model in rats and rabbits for Dr. Catling (and previously Dr. Park) who study pathophysiology of vasucular injury. The addition of a Millar Conductance Catheter system has given us the ability to study cardiac function in rats and mice in vivo. A major service of the Core has been providing ultrasound imaging. We have provided this service to Drs. Boulares, Wu and previously Dr. Park on the COBRE and to many other laboratories at LSUHSC and Tulane University. The data generated by the Core has led to several abstracts, grants (funded and pending) and contracts. Several manuscripts are also pending. In the near future we hope to add the capability to measure arterial blood gases and to conduct studies of respiratory function in conscious rodents.