Project 1

项目1侧重于整合由不同分子物种组成的不同水平的信息并在不同的时间尺度上运作这一根本挑战。特别是，将利用两个模型系统(酵母和盐生细菌)来开发方法，以了解管理来自环境的信息如何传播的原则和规则，以协调多种反应和复杂的表型。 我们将使用跨越信号、基因调控和新陈代谢网络的模型。通过该项目开发的工具和见解将适用于所有生物系统 发育的、生理的和结构的。 此外，信号传递过程的故障会导致表型和代谢。 人类疾病的潜在变化，包括癌症、神经疾病、肌病 还有糖尿病。了解这些网络的动态特性是一个窗口 了解疾病状态和合理的有效干预策略 医学系统观的基础。

Project 1 focuses on the fundamental challenge of integrating different levels of information comprising different molecular species and operating across different time scales. In particular, two model systems (yeast and halobacterium) will be exploited to develop approaches for understanding the principles and rules governing how information from the environment is propagated to coordinate multiple responses and complex phenotypes. We will use models that traverse across signaling, gene regulatory and metabolic networks. Tools and insights developed through this project will be applicable to all biological system developmental, physiological and structural. Moreover, the malfunction of signaling processes leads to phenotypic and metabolic changes underlying human disease, including cancers, neuropathies, myopathies and diabetes. Understanding the dynamic nature of these networks is a window into understanding disease states and rational strategies for effective interventions the basis of a systems view of medicine.