Glove Rehabilitation Application for Stroke Patients (GRASP)

项目总结/摘要 简介：中风患者手套康复应用（GRASP）快速通道SBIR计划将 通过器械矫形器促进中风后手功能的恢复， 在虚拟环境中的有趣和参与活动中练习手动任务。努力结合 专利传感器手套技术开发下，美国宇航局航天服计划与商业手 矫形器和现代游戏引擎技术。GRASP将自动评估患者的功能水平 并使挑战适应他/她的能力。在每次会话中，系统将自动生成有效的 手部功能的指标，为患者和提供者提供有关状态的即时反馈， 中求进工作总低成本的产品将支持独立的家庭使用，以及作为治疗师的一部分， 指导住院病人，熟练的护理，门诊病人，家庭健康，或远程治疗康复计划。 有待解决的问题：大型类人猿生存项目解决以下关键挑战：（1）改善现有成果 通过任务导向的实践和心理意象治疗，促进功能恢复;（2）使 通过独立的家庭使用和远程治疗增加剂量、强度和持续时间;（3）最大限度地减少总 通过减少病人/治疗师的旅行来减少康复费用;以及（4）改善服务不足地区的服务。 长期目标：改善获得性脑损伤患者的结局和功能独立性。 第一阶段概述：快速通道的第一阶段将产生一个由传感器组成的原型系统， 软件包和软件应用程序，允许商业手套矫形器用于虚拟实践 日常生活活动（ADL）在一个引人注目的虚拟世界。弗吉尼亚大学进行的一项试点研究 (UVa)，UVa HealthSouth康复医院和Continuum Home Health将调查主要的 第一阶段假设，该假设指出，GRASP生成的指标与公认的 手部功能的测量。由家庭健康治疗师领导的两个第一阶段案例研究将探索 家庭环境，并作为第二阶段疗效试验的探路者。 第二阶段概述：快速通道的第二阶段将包括：（1）开发商业系统;（2） 手治疗活动范围的扩展和虚拟环境的扩展，以提供一个引人入胜的 在8周的治疗中获得激励经验;（3）提供处方和监测工具 状态/进展;和（4）远程治疗接口。一项II期疗效研究将调查 GRASP家庭治疗与标准护理的标准化评估评分和依从性。随机分组， 对照试验将由UVa与HealthSouth和Continuum Home Health合作领导。 商业机会：每年因中风住院的80万人中约有50% 在美国，患有手部和/或手臂功能的慢性缺陷[1]，[2]。GRASP准备迅速过渡到 通过利用具有明确分销渠道的现有品牌，将基于证据的研究推向市场。

PROJECT SUMMARY/ABSTRACT Introduction: The Glove Rehabilitation Application for Stroke Patients (GRASP) Fast-Track SBIR program will promote recovery of hand function following stroke through an instrumented orthosis that enables functional practice of manual tasks in fun and engaging activities within a virtual environment. The effort combines patented sensor glove technology developed under the NASA space suit program with a commercial hand orthosis and modern game engine technology. GRASP will automatically assess a patient's functional level and adapt the challenge to his/her capabilities. In each session, the system will automatically produce valid metrics of hand function, providing both patients and providers with immediate feedback on status and progress. The low-cost product will support independent home use as well as serve as part of a therapist- guided in-patient, skilled nursing, outpatient, home health, or teletherapy rehabilitation program. Problem to be addressed: GRASP addresses the critical challenges of: (1) improving outcomes in hand therapy through task-directed practice and mental imagery that promote functional recovery; (2) enabling increased dosage, intensity, and duration through independent home use and teletherapy; (3) minimizing total cost of rehabilitation by reducing patient/therapist travel; and (4) improving services in underserved areas. Long-Term Goal: Improved outcomes and functional independence for patients with acquired brain injury. Phase I Summary: Phase I of the Fast-Track will produce a prototype system that consists of a sensor package and software application that permits a commercial glove orthosis to be used for practice of virtual activities of daily living (ADLs) in a compelling virtual world. A pilot study conducted by the University of Virginia (UVa), UVa HealthSouth Rehabilitation Hospital, and Continuum Home Health will investigate the primary Phase I hypothesis, which states that GRASP-generated metrics correlate significantly with accepted measures of hand function. Two Phase I case studies led by home health therapists will explore usability in the home environment and serve as pathfinders for Phase II efficacy trials. Phase II Summary: Phase II of the Fast-Track will include: (1) development of a commercial system; (2) extension of the range of hand therapy activities and expansion of virtual environments to provide an engaging and motivating experience across 8 weeks of treatment; (3) provider tools for prescribing and monitoring status/progress; and (4) teletherapy interfaces. A Phase II efficacy study will investigate improvement in standardized assessment scores and adherence for GRASP at-home therapy vs. standard care. Randomized, controlled trials will be led by UVa in partnership with HealthSouth and Continuum Home Health. Commercial Opportunity: Approximately 50% of the 800,000 individuals hospitalized due to stroke each year in the U.S. suffer from chronic deficits in hand and/or arm function [1], [2]. GRASP is poised to rapidly transition evidence-based research to market by leveraging an existing brand with well-defined distribution channels.