Core H: Latino Core

摘要-拉丁核心 拉什阿尔茨海默病核心中心（拉什ADCC; P30 AG 10161）支持的性能， 在AD的病因、发病机制、诊断、治疗和预防及相关领域的创新研究 条件，通过为研究人员提供一个刺激的跨学科的环境，独特的，高度 有价值的临床和尸检数据以及生物样本。Rush ADCC有八个内核，支持 各种及时和重要的研究领域，包括从正常老龄化过渡到 MCI到AD，正常衰老和MCI的神经生物学，以及现代组学技术的使用， 确定新的治疗靶点。 拉什ADCC已经招募了大量的黑人和白人没有痴呆症的临床和 宗教秩序研究核心。虽然拉丁裔社区一直不是一个主要的焦点，相当大的 迄今为止，拉丁裔社区的进步为拉丁裔核心奠定了基础。拉丁美洲人的总体目标 核心，在2015年8月资助，是登记和跟踪老年人无痴呆症的基线， 生成数据和生前和死后的生物标本，以支持高质量，尖端， 外部资助的研究，重点是全方位的认知。这些目标将通过 四个具体目标旨在加强拉什ADCC和更广泛的ADC研究社区： 目标1是招募和登记没有痴呆症的老年拉丁美洲人，他们同意每年进行详细的临床评估 以及收集死前生物样本目标2是进行统一的结构化基线， 年度随访评价，包括神经系统检查以及神经心理和运动 性能测试，社区居住的拉丁美洲人，并适用于事件AD统一的诊断标准， MCI，并与宗教秩序研究核心和临床核心协调数据收集，以促进 健康差异研究。目标3是将创新和文化定制的教育计划融入 临床评价，以提高认识的重要性，脑和脊髓尸检的拉丁美洲人， 以促进高尸检率和短的死后间隔;并在 保持最大的灵活性，以支持各种各样的研究。目标4：提高能力 进行外部资助的研究，包括将当代生物化学和 分子技术和临床试验，通过提供一个环境和资源，以促进纳入 将受试者、临床数据和死后组织纳入研究项目，并为以下人员提供培训机会： 初级教员。

ABSTRACT - LATINO CORE The Rush Alzheimer's Disease Core Center (Rush ADCC; P30AG10161) supports the performance of innovative research on the etiology, pathogenesis, diagnosis, treatment, and prevention of AD and related conditions, by providing researchers with a stimulating inter-disciplinary environment, and unique and highly valued clinical and post-mortem data, and biologic specimens. The Rush ADCC has eight cores that support a variety of timely and important areas of research including risk factors for the transition from normal aging to MCI to AD, the neurobiology of normal aging and MCI, and the use of contemporary omics technologies to identify novel therapeutic targets. The Rush ADCC has enrolled large numbers of Blacks and Whites without dementia into the Clinical and Religious Orders Study Cores. Although the Latino community has not been a major focus, considerable progress in the Latino community to date has set the stage for the Latino Core. The overall goal of the Latino Core, funded in August, 2015, is to enroll and follow older Latinos free of dementia at baseline, and generate data and ante- and post-mortem biospecimens, to support high quality, cutting edge, externally-funded studies that focus on the full spectrum of cognition. These goals will be addressed with four Specific Aims designed to enhance the Rush ADCC and the wider ADC research community: Aim 1 is to recruit and enroll older Latinos without dementia who agree to annual, detailed clinical evaluations and the collection of ante-mortem biologic specimens. Aim 2 is to conduct uniform structured baseline and annual follow-up evaluations, including neurological examinations and neuropsychological and motor performance testing, of community-dwelling Latinos, and apply uniform diagnostic criteria for incident AD and MCI, and harmonize data collection with the Religious Orders Study Core and the Clinical Core to facilitate health disparities research. Aim 3 is to integrate innovative and culturally tailored educational programs into the clinical evaluation to increase awareness of the importance of brain and spinal cord autopsy in Latinos and to facilitate a high autopsy rate with a short post-mortem interval; and harvest and preserve brain tissue in a fashion that retains maximum flexibility to support a diverse array of studies. Aim 4 is to increase the capacity to conduct externally-funded research, including studies that incorporate contemporary biochemical and molecular techniques and clinical trials, by providing an environment and resources to facilitate the inclusion of subjects, clinical data, and post-mortem tissue into research projects and to provide training opportunities for junior faculty.