Analytics and Synthesis Core

项目摘要 烟草监管科学（TRS）的新发现正在迅速发展，但将这些发现转化为 更有力的研究实践和政策的进展面临着巨大的挑战，包括综合 并向各利益攸关方传播这些调查结果。此外，作为烟草产品， 景观继续发展，需要新的TRS研究，以及进一步的整合，以帮助通知 FDA的监管措施。一个强大的协调中心，作为TRS研究人员的枢纽和连接器， 对于克服这些挑战和促进有效的TRS研究至关重要。我们设计了我们的 分析、科学、增强和物流协调中心（CASEL）应对挑战 面对这个快速变化的环境和不断扩大的知识基础。我们的具体目标是：（1）服务 作为TRS的科学研究协调员，通过促进合作和传播， 科学和知情的现金转拨方案规则制定;并通过支持采用协商一致的方法和措施， 数据共享和综合;（2）通过促进沟通，协调， 信息共享的机会，并使研究资源容易获得的TRS社区; (3)通过支持职业发展，提高研究人员开展有影响力研究的能力 （4）建立后勤和管理基础设施 有效协调TRS研究的多样化组合;（5）提供科学专业知识 和观点，以帮助确定研究需求和与之合作的手段。 联邦合作伙伴和研究界来解决这些问题;和（6）作为NIH，CTP， 和烟草监管科学中心（TCORS），以提高和加快产量， 开展快速反应项目，解决高度优先问题。我们将以一种 协作结构，建立在我们经验丰富的科学和管理领导，完善的 基础设施，以及将不同团队聚集在一起的能力，使CASEL成为成功和支持性的合作伙伴 推进TRS。我们举办了前身培训评估和协调中心， 研究（CECTR），从而拥有丰富的资源，经验，组织和建立TRS 网络无缝地进入CASEL，加强和扩大我们的举措，并引入细致入微， 在我们的方法有效创新。Jeanne Rosenthal和Robin Mermelstein博士将担任Co-PI， 领导和后勤核心的领导者，提供高层次的管理和国家认可的 分别科学领导。我们经验丰富的核心领导，霍华德菲什拜因博士（分析和 Amy Solis女士（职业发展）和Cassandra Stanton博士（传播）将提供 有效和有知识的监督，以满足每个核心的具体目标。我们聚集了广泛的 一系列的合作者，以创造一个理想的环境，以促进和促进高质量的TRS的行为。

PROJECT ABSTRACT New discoveries in Tobacco Regulatory Science (TRS) are occurring at a rapid pace, but translating these advances into more robust research practices and policy faces enormous challenges, including the synthesis and dissemination of these findings to reach a variety of stakeholders. In addition, as the tobacco product landscape continues to evolve, new TRS research is needed, as well as further integration to help inform the FDA’s regulatory actions. A strong coordinating center, serving as a hub and connector for TRS researchers, is critical to overcoming these challenges and to promoting effective TRS research. We have designed our Center for Coordination of Analytics, Science, Enhancement and Logistics (CASEL) to address challenges faced by this rapidly changing environment and expanding knowledge base. Our specific aims are to: (1) Serve as the scientific research coordinator for TRS by facilitating collaboration and dissemination to advance the science and inform CTP rule-making; and by supporting the adoption of consensus methods and measures, data sharing, and synthesis; (2) Accelerate the progress of TRS by fostering communication, coordinating information-sharing opportunities, and making research resources readily accessible to the TRS community; (3) Enhance the capacity of researchers to conduct impactful research by supporting career enhancement activities across the CTP-funded research community; (4) Establish a logistical and management infrastructure for efficient and effective coordination of a diverse portfolio of TRS research; (5) Provide the scientific expertise and perspective to contribute to the identification of research needs and the means to work cooperatively with Federal partners and the research community to address them; and (6) Serve as a conduit between NIH, CTP, and the Tobacco Centers of Regulatory Science (TCORS) to enhance and accelerate output and facilitate the conduct of rapid response projects to address high-priority questions. We will accomplish these aims with a collaborative structure that builds on our experienced scientific and management leadership, well-developed infrastructure, and ability to bring diverse teams together to make CASEL a successful and supportive partner in advancing TRS. We have held the predecessor Center for Evaluation and Coordination of Training and Research (CECTR), and thus have a wealth of resources, experience, organization, and an established TRS network to step into CASEL seamlessly, to enhance and expand our initiatives, and to introduce nuanced, effective innovation in our approaches. Jeanne Rosenthal and Dr. Robin Mermelstein will serve as Co-PIs and leaders of the Leadership and Logistics Core, providing high-level management and nationally recognized scientific leadership respectively. Our highly experienced Core Leads, Dr. Howard Fishbein (Analytics and Synthesis), Ms. Amy Solis (Career Enhancement), and Dr. Cassandra Stanton (Dissemination), will provide effective and knowledgeable oversight to meet each core’s specific aims. We have brought together a wide range of collaborators to create an ideal environment to foster and promote the conduct of high quality TRS.