SCH: Implantable Spectrometers for Health Monitoring

 描述（由申请人提供）：我们建议将紧凑型激光源、微谐振器和光电探测器集成在无线电源和数据通信平台上，以创建植入式健康监测器。这些传感器系统具有亚毫米级的尺寸，小到足以适应血管，并且能够连续测量，向外部读取器报告数据。我们的小型化方法依赖于远程为设备供电，以脉冲模式操作传感器，并通过使用局部加热保持测量表面清洁。我们已经展示了这样一个系统的所有单独组件，以产生非常灵敏的检测和高保真的数据通信，并建议将这些系统集成和功能化，以监测慢性健康状况。对体内分析物的连续监测能够早期检测疾病，以及更深入地了解疾病进展和身体反应。 我们已经展示了无线连续葡萄糖监测仪，并打算提供其他代谢物的连续测量，用于监测心血管疾病和癌症。这种方法还使患者能够真实的优化他们的行为和药物治疗。 除了重要的临床信息之外，位于循环系统内或附近的小型传感器可以在生物体受到疾病和其他生理压力时提供有关生物体内生化变化的快速代谢数据。用于监测分析物或核酸的紧凑型无线传感器平台的开发将最终实现对疾病的诊断和治疗的更多分析方法，并允许在个体动物模型中连续观察疾病的进展。

 DESCRIPTION (provided by applicant): We propose to integrate compact laser sources, microresonators and photodetectors on wireless power supplies and data communications platforms to create implantable health monitors. With sub-millimeter dimensions, these sensor systems will be small enough to fit into blood vessels and will be able to measure continuously, reporting data to an external reader. Our miniaturization approach relies on remotely powering the devices, operating the sensors in pulsed mode, and keeping the measurement surfaces clean by using local heating. We have shown all ofthe individual components of such a system to yield very sensitive detection and high fidelity data communications, and propose to integrate and functionalize these systems to monitor chronic health conditions.: Continuous monitoring of analytes within the body enables the early detection of disease, as well as a more profound understanding of disease progression and body response. We have demonstrated wireless continuous glucose monitors, and intend to provide continuous measurement of other metabolites for the monitoring of caridovascular diseases and cancers. This approach also empowers patients to optimize their behavior and medication in real time. Beyond the important clinical information, small sensors located within or close to the circulatory system can provide rapid metabolic data on the biochemical changes within living organisms when these are subjected to disease and other physiological stress. The development of compact wireless sensor platforms for the monitoring of analytes or nucleic acids will ultimately enable a more analytical approach towards the diagnosis and treatment of diseases, and allow the continuous observation of the progression of diseases in individual animal models.