Methodology Core

方法/数据管理核心对西北大学的成功至关重要 MCRC大学。数据库和研究表格开发方面的专业知识的集中使用；数据 监测、数据输入和检索；以及用于检验假设和控制的各种分析技术 因为潜在的混杂因素对现有和新的调查人员都是必不可少的资源。识别 更新的分析技术已经变得可用，并在医学文献中被更多地接受，这 建议继续扩展我们在临床流行病学和卫生服务研究方面的工作。 以前实施的。鉴于该中心对纵向研究的重视，高级专家 统计技术[广义估计方程(GEE)、离散生存时间回归分析 以及荟萃分析、分类和回归树(CART)]、经济学、决策分析、临床 流行病学、行为科学和基因组学被列为核心研究人员。新的专业知识 现在包括患者报告的结果测量、饮食/体力活动测量和生物信息学。 核心为所有3个拟议的项目提供基本的方法、数据完整性和安全计划功能 Mcrc项目。此外，这一核心将继续为关节炎研究社区提供更广泛的服务 通过提供一个鼓励核心方法学家和员工之间协作的环境，以及 每一项临床、流行病学和卫生服务关节炎研究的附属于mCRC的教员和实习生 西北大学提出并实施的项目。通过它与西北大学的积极关系 范伯格大学医学院(NU-FSM)预防医学、物理医学 康复学、医学社会科学、卫生保健研究所和国立大学临床与医学研究所 翻译科学(NUCATS)研究所，MCRC方法学/数据管理核心能够绘制 关于相关人才和专业知识的多元化大学社区不仅有助于解决研究 与NIAMS感兴趣的各种风湿病条件有关的项目的挑战(例如， 骨关节炎、类风湿性关节炎、系统性红斑狼疮、硬皮病)，还能促进和 支持这些领域的跨学科团队研究。核心是由经验丰富的风湿病专家领导的 调查员，包括高级和初级教员方法学家以及经验丰富的统计人员 分析师和程序员/数据库经理。西北大学NIAMS P60的多年核心 业务程序已经演变，以最大限度地提高教育服务的成本效益和质量。

The Methodology/Data Management Core is critically important to the success of the Northwestern University MCRC. The centralized availability of expertise in database and study form development; data monitoring, data entry and retrieval; and the various analytic techniques used to test hypotheses and control for potential confounders are essential resources for both established and new investigators. Recogniz ng that newer analytic techniques have become available and more accepted in the medical literature, this proposal continues the expansion of our work in clinical epidemiology and health services research previously implemented. Given this Center's emphasis on longitudinal research, experts in advanced statistical techniques [generalized estimating equations (GEE), discrete survival time regression analysis, as well as meta-analysis and classification and regression trees (CART)], economics, decision analysis, clinical epidemiology, behavioral science, and genomics are included as Core investigators. New expertise in patient reported outcome measures, diet/physical activity measurement, and bioinformatics is now included. The Core provides essential methodological, data integrity, and safety plan functions for all 3 proposed MCRC projects. In addition, this Core will continue to serve the arthritis research community more broadly by providing an environment that encourages collaboration between Core methodologists and staff and MCRC-affiliated faculty and trainees on every clinical, epidemiologic, and health services arthritis reseai'ch project proposed and implemented at Northwestern. Through its active relationships with the Northwestern University Feinberg School of Medicine's (NU-FSM) Departments of Preventive Medicine, Physical Medicine & Rehabilitation, and Medical Social Sciences, the Institute for Healthcare Studies, and the NU Clinical and Translational Science (NUCATS) Institute, the MCRC Methodology/Data Management Core is able to draw on the relevant talent and expertise of a diverse University community to not only help solve the research challenges of projects pertaining to a variety of rheumatologic conditions of interest to NIAMS (e.g., osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus, scleroderma), but also to promote and sustain interdisciplinary team research in these fields. The Core is led by a seasoned rheumatology investigator and includes both senior and junior faculty methodologists as well as experienced statistical analysts and programmers/database managers. Over the years of Northwestern's NIAMS P60, Core operational procedures have evolved to maximize cost-effectiveness and quality of educational offerings.