The PDX Integrator- Re-purposing KOMP2 informatics to widely disseminate data from Patient Derived Xenografts

 描述(由申请人提供)：患者来源的异种移植物是癌症生物学的一个重要且不断增长的资源。它们提供了对癌症进展、治疗的了解，并代表了一种宝贵的综合资源。这些数据包括与小鼠模型中的肿瘤及其进展相关的复杂的Meta数据。组学、药物、化验和图像数据提供了对PDX的丰富表征，并提供了与现有工具、数据档案和分析平台的集成潜力。PDX集成器将建立在为KnoKout Mouse Project 2开发的现有基础设施之上，有四项任务：1)确定PDX模型中的关键决定因素，映射到现有数据标准，并与社区合作定义、扩展并在必要时修改现有标准2)扩展现有KOMP2数据采集软件，以获取、验证和加载PDX相关数据3)部署PDX集成器，通过采用KOMP2资源数据可视化和演示工具，提供用户友好的PDX数据概述，包括生物图像数据和终端数据的图形可视化。4)在项目的所有阶段进行有针对性的社区推广，以确定需求并确定其优先顺序，指导开发并推广PDX集成商。

 DESCRIPTION (provided by applicant): Patient Derived Xenografts are a critical and growing resource for cancer biology. They inform the understanding of cancer progression, treatment and represent a valuable and under integrated resource. These data consist of complex Meta data related to the tumor and its progression in mouse model. Omics, drug, assay and image data provide rich characterization of PDXs and offer integration potential with existing tools, dat archives and analysis platforms. The PDX Integrator will build on existing infrastructure developed for the Knockout Mouse Project 2 and has four tasks: 1) Identify key determinants in PDX models, map to existing data standards and work with the community to define, extend and where necessary modify existing standards 2) Extend the existing KOMP2 data acquisition software to acquire, validate and load PDX associated data 3) Deploy the PDX Integrator to provide user friendly overviews of PDX data including biological image data and graphical visualization of end-point data by adapting the KOMP2 resource data visualization and presentation tools. 4) Targeted community outreach during all stages of the project to determine and prioritize requirements, guide development and promote the PDX Integrator.