Title: Pharmacokinetic and Bioavailability Studies and Analytical Support with Selected Anticancer Compounds in Mice.Period of Performance: 6/27/17 - 4/27/2022

本任务令的目的是描述如下所述的小分子候选抗癌化合物在小鼠体内的血浆药代动力学（PK）和生物利用度，并可选地为NCI提供的血浆和/或肿瘤样本中此类抗癌药物的定量提供分析支持。需要迅速扭转局面。该任务订单有一个基期和备选项。

The purpose of this Task Order is to characterize the plasma pharmacokinetics (PK) and bioavailability of small molecule candidate anticancer compounds in mice as outlined below and optionally, provide analytical support for the quantification of such anticancer agents in plasma and/or tumor samples to be provided by NCI. Rapid turn-around is required. There is a base period and options under this task order.