Integrative Training in Oncogenic Signaling

项目摘要/摘要 这项提议寻求国家癌症研究所(NCI)对激动人心的综合培训的支持 癌基因信号(ITOS)计划已由选定的癌症科学家附属小组开发 与南卡罗来纳医科大学霍林斯癌症中心(HCC)合作。伊藤忠商事 计划发生在这个活跃且不断增长的医疗中心环境中，拥有最先进的设施， 充满活力的NCI指定的癌症中心，以及一个活跃的博士后事务办公室。由计划总监领导 凭借非常强大的癌症研究背景和领导经验，ITOS计划将 挑选和支持受训人员在有经验、资金充足、富有成效的实验室工作 驻留在交互式、多部门研究环境中的计划学院，具有广泛的 资源。每名学员将有一名主要导师和一名或两名辅助导师，并相互补充 确保独特和有价值的观点的专业知识，这将加强与癌症相关的整体研究 培训经验。该培训计划的目标是提供积极的指导和监督 和尖端方法的研究培训；发展有用的学术和必要的职业生涯 发展技能；促进与教员和其他受训人员的协作、跨学科互动；以及 提供对当前癌症研究发现的接触，以及这些发现如何转化为小说 癌症的预防、诊断和治疗方法。 计划在五年内每年培训五名博士后实习生，这个强有力的培训机会有七个 实现上述目标所必需的方案组成部分。其中包括以下内容 组成部分：1)33名在癌症研究方面有共同兴趣的计划教职员工，并将提供 为学员提供必要的指导；2)有一到两年在以下专业实验室工作的经验 充满活力的肝细胞癌研究环境；3)提供引人入胜的社区的ITOS计划研究俱乐部 为学员和项目教员提供的论坛，以讨论正在进行的工作以及 癌症科学；4)与前沿专家共享研究资源研讨会和量身定做的培训 生物技术；5)与受训人员进行跨学科接触，参加由癌症委员会赞助的主题研究务虚会， 研讨会、进行中工作会议和研讨会；6)职业发展讲习班和课程，将 为学员的独立成功做好准备；以及7)至少有两个在全国范围内建立关系网的机会 每年的专业会议。总而言之，ITOS计划将提供独特的经验和 仅向选定的伊藤忠研究员提供机会，该方案由#名杰出干部领导 计划学院，预计将对当地和全国新兴的初级调查人员具有极大的吸引力。

PROJECT SUMMARY/ABSTRACT This proposal seeks National Cancer Institute (NCI) support for an exciting new Integrative Training in Oncogenic Signaling (ITOS) Program that has been developed by a select group of cancer scientists affiliated with the Hollings Cancer Center (HCC) at the Medical University of South Carolina (MUSC). The ITOS Program takes place in this active and growing medical center environment with state-of-the-art facilities, a vibrant NCI-designated cancer center, and an active Office of Postdoctoral Affairs. Led by a Program Director with an exceptionally strong cancer research background and leadership experience, the ITOS Program will select and support the placement of trainees in experienced, well-funded, productive laboratories led by the Program Faculty who reside in an interactive, multi-departmental research environment with extensive resources. Each trainee will have a primary mentor and one or two secondary mentors with complementary expertise to ensure distinct and valuable perspectives that will enhance the overall cancer-related research training experience. The objectives of this training program are to provide proactive mentoring and oversight and research training in cutting-edge methodology; to develop useful academic and essential career development skills; to foster collaborative, interdisciplinary interactions with faculty and other trainees; and to provide exposure to current cancer research discoveries and how these are being translated into novel approaches to prevention, diagnosis, and treatment of cancer. Slated to train five postdoctoral trainees each year for five years, this robust training opportunity has seven programmatic components essential in obtaining the aforementioned objectives. These include the following components: 1) 33 Program Faculty who share common interests in cancer research and will provide the essential mentoring for trainees; 2) one to two year experiences in Program Faculty laboratories found within the vibrant HCC research environment; 3) an ITOS Program Research Club providing an engaging community forum for the trainees and Program Faculty to discuss work in progress as well as the latest discoveries in cancer science; 4) shared research resource workshops and tailored training with experts in cutting-edge biotechnologies; 5) interdisciplinary engagement with trainees in HCC-sponsored thematic research retreats, symposia, work in progress meetings, and seminars; 6) career development workshops and courses that will equip trainees for independent success; and 7) opportunities to network nationally at a minimum of two professional conferences each year. In summary, the ITOS Program will offer distinct experiences and opportunities only afforded to the selected ITOS Fellows, and the program, led by an outstanding cadre of Program Faculty, is anticipated to be highly attractive to emerging junior investigators locally and nationally.