Imaging Core

成像核心将对小鼠肿瘤模型进行所有磁共振和生物发光成像研究 项目1和2。此外，成像核心负责所有临床前和临床数据的存档， 后处理和分析。核心人员将提供的服务包括：(A)定义和实施数据 采集/成像序列；(B)协助动物准备成像；(C)执行所有数据收集 9.4特斯拉核磁共振、7特斯拉核磁共振和卡利珀生物发光成像系统；(D)初步数据 处理/图像重建和定量分析，包括临床前的PRM分析 (项目1和2)和临床影像数据(项目3)和结果数据；(E)原始数据的安全存档 以及来自非现场设施的重建数据的网络传输；(F)成像实验的安排；以及 (G)在成像实验的技术设计和实施方面向方案调查人员提供支助。 这些服务在一定程度上是在连续的、大容量的动物模型之后设计的 扫描是每个项目成功的关键，具体的动物磁共振成像方案将因每个项目而异 项目，但主要将包括系列研究，使用：标准T2加权；TL加权动态对比 多层定量水扩散图与动态对比增强渗透率 映射。核心还将有助于确定小鼠活组织检查所需的空间坐标 使用立体定向术治疗胶质瘤，并使这一活动变得容易。核心还将协助转移MR 将数据提供给IMBIO，LLC，用于对在多个地点采集的磁共振扩散和灌注数据集进行异地分析。Dr。 加尔班将担任核心B董事。加尔班博士在小动物成像研究方面拥有丰富的经验 以及临床MRI数据的数字图像处理和分析。一名联合调查员和工作人员将协助 Galban博士采用图像处理算法和相关分析软件，以确保 这一规划研究工作的需要得到了充分满足。

The Imaging Core will perform all MR and bioluminescence imaging studies on mouse tumor models for Projects 1 and 2. In addition, the Imaging Core is responsible for all preclinical and clinical data archiving, post-processing and analysis. Core personnel will provide services including: (a) define and implement data acquisition/imaging sequences; (b) assist with animal preparation for imaging; (c) perform all data collection on the 9.4 Tesla MRI, 7 Tesla MRI and Caliper bioluminescence imaging systems; (d) preliminary data processing/image reconstruction and quantitative analysis including PRM analysis for both preclinical (Projects 1 and 2) and clinical imaging data (Project #3) and outcomes data; (e) secure archival of raw data and network transfer of reconstructed data from off-site facilities; (f) scheduling of imaging experiments; and (g) provide support to Program Investigators in technical design and implementation of imaging experiments. These services are designed, in part, after a "clinical MRI service" model since continual, high-volume animal scanning is essential for the success of each project Specific animal MRI protocols will vary with each project, but will primarily include serial studies using: standard T2-weighted; Tl-weighted dynamic contrast enhanced; multislice quantitative water diffusion mapping and dynamic contrast enhancing permeability mapping. The Core will also facilitate the identification of the spatial coordinates needed for biopsy of mouse gliomas using stereotaxic procedures and facilite this activity. The Core will also assist with transfer of MR data to Imbio, LLC for offsite analysis of diffusion and perfusion MRI data sets acquired at multiple sites. Dr. Galban will serve as Core B Director. Dr. Galban has extensive experience in small animal imaging research as well as digital image processing and analysis of clinical MRI data. A Co-investigator and staff will assist Dr. Galban with adapting image processing algorithm's and associated analysis software to ensure the needs of this programmatic research effort are fully met.