Career Development and Mentoring in Clinical/Translational Alcohol Research

描述（由申请人提供）：高级科学家研究和指导奖是针对“在生物医学研究中表现出持续高生产力水平的杰出高级科学家”的，目的是保护他们继续研究的时间，同时指导“下一代”研究人员。拥有超过25年的临床酒精研究经验（超过20个临床试验，在渴望（OCDS），饮酒生物标志物（CDT），神经影像学，以及最近在遗传和药物基因组学方面的开创性工作），超过15年的持续R01资助，16年的酒精研究中心科学主任，拥有245篇同行评审出版物和国际认可，候选人满足并超越了作为一名杰出的高级科学家的要求。他曾被选为领先学术/研究协会的高级领导职位，是COMBINE研究的前任领导者，并因其在弥合基础研究和临床研究之间的差距方面的专业知识而被寻求作为导师。在完成这些工作的同时，他还积极参与酒精研究的培训项目，包括担任niaaa赞助的T32研究培训基金的主任或联合主任20年。他亲自指导了34名专业人员（23名博士，11名博士），其中20名是在过去的4年里。许多人已经获得了职业发展和独立的酒精研究资金，并继续与酒精领域联系在一起。他对酒精障碍治疗的机制和应用的理解是非典型和罕见的。这个奖项对候选人来说很重要，主要有两个原因。首先，这将为他提供受保护的时间，使他能够继续在遗传学（如表观遗传学）、蛋白质组学（如糖蛋白组学）和新的/先进的神经成像技能（fMRI连接分析、扩散峰度和h1磁共振波谱）方面接受正式和非正式的培训，使他的酒精研究事业保持在前沿，并将这些重要的科学领域应用于他自己的酒精研究（如所述）。并向整个酒精治疗领域传达新发现。其次，该奖项将为候选人提供额外的临床和行政职责的保护时间，将其丰富的经验和新获得的技能应用于他的指导活动和年轻临床科学家的发展。美国国立卫生研究院（NIH）和美国医学院协会（American Association of Medical Colleges）强调，美国对临床和转化研究人员（尤其是基因组学领域）的巨大需求尚未得到满足，数百万美国人患有酒精障碍，他们得不到充分的服务，每年给美国经济造成超过2000亿美元的损失，因此有必要推动临床研究向前发展，有必要确保我们的资深科学家在自己的研究中处于前沿。而且需要培养未来的科学家来进行这项研究，以找到有效的治疗方法。K05高级科学家职业和指导奖将使这一切成为可能。

DESCRIPTION (provided by applicant): The Senior Scientist Research and Mentorship Award is targeted for "outstanding senior scientists who have demonstrated a sustained level of high productivity conducting biomedical research" in order to protect their time to continue research while mentoring the "next generation" of investigators. With more than 25 years of experience in clinical alcohol research (over 20 clinical trials, seminal work in craving (OCDS), biomarkers of drinking (CDT), neuroimaging, and more recently in genetic and pharmacogenomics), over 15 years of continued R01 funding, 16 years of being a Scientific Director of an Alcohol Research Center, with 245 peer reviewed publications, and international recognition, the candidate meets and exceeds the requirements as an outstanding senior scientist. He has been elected to high leadership positions of leading academic/research societies, a previous leader of the COMBINE Study, and is sought out as a mentor for his expertise in bridging the gap between basic and clinical research. He has accomplished this while maintaining an active training program in alcohol research, including 20 years as Director or Co-Director of an NIAAA-sponsored T32 Research Training Grant. He has personally mentored 34 professionals (23 MDs and 11 PhDs), 20 of those in the past 4 years. Many have secured career development and independent alcohol research funding and remain tied to the alcohol field. His understanding of both the mechanisms of, and applications to, the treatment of alcohol disorders is atypical and rare. This award is important to the candidate for two major reasons. First, it will provide him with protected time to keep his alcohol research career on the cutting edge by enabling him to continue formal and informal training in genetics (e.g. epigenetics), proteomics (e.g. glycoproteomics), and new/advanced neuroimaging skills (fMRI connectivity analysis, diffusion kurtosis, and H1-magnetic resonance spectroscopy), apply these essential areas of science to his own alcohol research (as outlined), and communicate new discoveries to the alcohol treatment field in general. Second, this award will provide the candidate with protected time from additional clinical and administrative duties to apply his vast experience and newly acquired skills to his mentoring activities and the development of younger clinical- scientists. With the NIH and the American Association of Medical Colleges highlighting the large, unmet need in the U.S. for clinical and translational researchers (especially in the area of genomics) and with millions of Americans suffering from alcohol disorders, who are underserved and who cost the US economy over $200 billion each year, there is a need to push clinical research forward, a need to ensure our senior scientists are on the cutting edge in their own research, and a need to train future scientists to carry on this research to find effective treatments. This K05 Senior Scientist Career and Mentoring Award will allow this to happen.