Dysregulated cholinergic transmission contributes to aging of the lower motor system

项目总结/摘要 随着年龄的增长而发生的运动功能的丧失与不利的健康状况密切相关 结果。到目前为止，运动系统的不同组成部分对年龄相关性的贡献 运动缺陷仍然未知，尽管进行了广泛的努力。此外，没有 可以预防导致运动功能丧失的细胞和分子变化的治疗方法 功能老化。本建议的目的是确定 神经肌肉系统的运动功能丧失。我们还寻求确定和测试 维持健康的骨骼肌和脊髓中的运动神经元， 保持运动功能。具体而言，我们将确定是否维持正常水平的 乙酰胆碱，从遗传上来说，足以减缓骨骼肌的衰老。 和运动神经元。

Project Summary/ Abstract The loss of motor function that occurs with aging is closely associated with adverse health outcomes. To date, the contribution of different components of the motor system to age-related motor deficits remains unknown and despite extensive efforts. In addition, there are no therapeutics that can prevent the cellular and molecular changes that underlie loss of motor function with aging. The purpose of this proposal is to identify the contribution of the neuromuscular system to loss of motor function. We also seek to identify and test factors that function to maintain healthy skeletal muscles and motor neurons in the spinal cord, and thus preserve motor function. Specifically, we will determine whether maintaining normal levels of acetylcholine, genetically and pharmacologically, is sufficient to slow aging of skeletal muscle and motor neurons.