Molecularly Imprinted Polymer-Carbon Nanotube Sensors for the Detection of Magnesium

项目摘要/摘要 镁(Mg2+)是所有细胞中的一种必需元素，与多种 生化过程和生理功能。人类体内对镁离子的不当调节与 糖尿病、高血压和免疫缺陷等疾病。因此，监测镁离子水平可能有助于 在这些疾病的诊断和治疗中；然而，目前测量镁离子的技术 不适用于快速的护理点分析，并且受到大量样品制备的需要的限制 或者对镁离子缺乏对其他阳离子的选择性。 该方案描述了一种杂化碳纳米管-分子印迹聚合物(CNT-MIP)抗化学性 传感器设计用于选择性地检测镁离子。拟议的系统由CNT网络组成，该网络由一个 一种功能性的二炔，在与镁离子结合时触发形成双自由基。在烯烃存在的情况下- 在含有单体的情况下，双自由基会引发聚合，并围绕镁离子络合物进行传播 模板分子。去除镁模板提供了具有结合腔的聚合物涂层的碳纳米管网络 它们对镁离子的识别具有很高的选择性，结合事件将使用 电导测量。因为功能烯二炔既是引发剂又是镁离子的结合 组，可以实现对CNT网络附近结合位点的精确空间控制，同时保持 从结合部位到CNT的直接连接。传感器的MIP部分预计将提供 具有结构健壮性和抗有害大电流泄漏的碳纳米管网络，通常 在基于碳纳米管的水基传感器中存在问题。

PROJECT SUMMARY/ABSTRACT Magnesium (Mg2+) is an essential element found in all cells and is intimately involved in a myriad of biochemical processes and physiological functions. Improper regulation of Mg2+ in humans has been linked to diseases such as diabetes, hypertension, and immunodeficiency. Therefore, monitoring Mg2+ levels could aid in diagnosis and treatment of these disease states; however, current technologies for measurement of Mg2+ are not amenable to rapid, point-of-care analysis, and are limited by a need for extensive sample preparation or a lack of selectivity for Mg2+ over other cations. This proposal describes a hybrid carbon nanotube-molecularly imprinted polymer (CNT-MIP) chemiresistive sensor designed to selectively detect Mg2+. The proposed system consists of a CNT network modified with a functional enediyne that triggers the formation of a diradical upon binding Mg2+. In the presence of alkene- containing monomers, the diradical initiates a polymerization that propagates around the Mg2+-complexed template molecule. Removal of the Mg2+ template affords a polymer-coated CNT network with binding cavities that are expected to be highly selective for the recognition of Mg2+, and the binding event will be detected using conductometric measurements. Because the functional enediyne acts as both an initiator and an Mg2+-binding group, precise spatial control of the binding sites near the CNT network can be achieved while maintaining a direct connection from the binding site to the CNT. The MIP portion of the sensor is expected to provide the CNT network with structural robustness and resistance to deleterious bulk current leakage, which is normally problematic in aqueous CNT-based sensors.