Understanding the context-dependent roles of mutations in lymphoma.
Understanding the context-dependent roles of mutations in lymphoma.
批准号:
9336685
负责人:
Sandeep Dave
金额:
$28.62万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-02-18 至 2019-08-31
关键词:
AccountingB-LymphocytesBiological ProcessBiologyCRISPR/Cas technologyClinicalComputing MethodologiesDNA Sequence AlterationDataData QualityDiseaseEmployee StrikesEventExclusionGene ExpressionGene Expression ProfileGene Expression ProfilingGene MutationGenerationsGenesGeneticGenetic HeterogeneityGoalsHeterogeneityHigh-Throughput Nucleotide SequencingHumanIn VitroIndividualInvestmentsKnockout MiceKnowledgeLinkLymphomaMalignant NeoplasmsMethodsModelingMolecularMolecular ProfilingMutateMutationOncogenicOutcomePathway interactionsPatient-Focused OutcomesPatientsPatternPhenotypeRecurrenceResearchRoleStructure of germinal center of lymph nodeSubgroupSystemTherapeuticTumor BiologyWorkbaseclinical phenotypeexome sequencinggenetic makeupimprovedin vivolarge cell Diffuse non-Hodgkin&aposs lymphomanext generation sequencingnovelnovel strategiesnovel therapeuticspublic health relevancescreeningtargeted sequencingtherapeutic targettranscriptometranscriptome sequencingtumor
中文摘要
描述(由申请人提供):我们小组和其他人最近的工作提供了大量关于淋巴瘤和其他肿瘤遗传组成的信息。然而,目前还不清楚这些基因突变实际上是如何导致疾病的,以及它们与已知生物过程和结果的相关程度。在这项提案中,我们试图研究不同的基因突变如何与已知的淋巴瘤表型和基因突变的背景依赖性作用相关。
英文摘要
DESCRIPTION (provided by applicant): Recent work from our group and others has provided a wealth of information regarding the genetic makeup of lymphomas and other tumors. However, it is unclear how these genetic mutations actually cause the disease and the degree to which they are associated with known biological processes and outcome. In this proposal, we seek to study how different genetic mutations are associated with known lymphoma phenotypes and the context-dependent roles of genetic mutations.
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专著(0)
科研奖励(0)
会议论文
Genetic Origins of Adverse Outcomes in African Americans with Lymphoma
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批准号:10587289
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项目类别:
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资助金额:$48.57万
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财政年份:2023
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负责人:Sandeep Dave
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依托单位:
Clinical and Genetic Origins of Monomorphic Epitheliotropic Intestinal T Cell Lymphoma
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批准号:10566317
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项目类别:
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资助金额:$41.66万
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财政年份:2023
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负责人:Sandeep Dave
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依托单位:
Targeting histone methylation in PTCL
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批准号:10477033
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项目类别:
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资助金额:$29.22万
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财政年份:2019
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负责人:Sandeep Dave
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依托单位:
Targeting histone methylation in PTCL
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批准号:9791868
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项目类别:
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资助金额:$31.76万
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财政年份:2019
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负责人:Sandeep Dave
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依托单位:
Targeting histone methylation in PTCL
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批准号:10673103
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项目类别:
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资助金额:$31.87万
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财政年份:2019
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负责人:Sandeep Dave
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依托单位:
Targeting histone methylation in PTCL
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批准号:10249204
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项目类别:
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资助金额:$29.81万
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财政年份:2019
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负责人:Sandeep Dave
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依托单位:
Targeting histone methylation in PTCL
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批准号:10005242
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项目类别:
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资助金额:$29.81万
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财政年份:2019
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负责人:Sandeep Dave
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依托单位:
Defining the Functional Role of Mutations in Diffuse Large B cell Lymphoma
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批准号:9040901
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项目类别:
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资助金额:$51.05万
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财政年份:2015
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负责人:Sandeep Dave
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依托单位:
The genetics of hepatosplenic T cell lymphoma
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批准号:8880794
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项目类别:
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资助金额:$21.71万
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财政年份:2015
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负责人:Sandeep Dave
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依托单位:
Exome-wide screening for common mutations in lymphoma
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批准号:8190377
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项目类别:
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资助金额:$20.28万
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财政年份:2011
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负责人:Sandeep Dave
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依托单位:
Exome-wide screening for common mutations in lymphoma
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批准号:8279186
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项目类别:
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资助金额:$16.85万
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财政年份:2011
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负责人:Sandeep Dave
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依托单位:
Molecular targets in diffuse large B cell lymphoma
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批准号:8204487
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项目类别:
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资助金额:$25.12万
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财政年份:2009
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负责人:Sandeep Dave
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依托单位:
Molecular targets in diffuse large B cell lymphoma
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批准号:8392181
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项目类别:
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资助金额:$23.61万
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财政年份:2009
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负责人:Sandeep Dave
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依托单位:
Understanding the context-dependent roles of mutations in lymphoma.
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批准号:8761919
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项目类别:
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资助金额:$28.32万
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财政年份:2009
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负责人:Sandeep Dave
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依托单位:
Molecular targets in diffuse large B cell lymphoma
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批准号:7566108
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项目类别:
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资助金额:$27.62万
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财政年份:2009
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负责人:Sandeep Dave
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依托单位:
Molecular targets in diffuse large B cell lymphoma
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批准号:7998215
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项目类别:
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资助金额:$25.12万
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财政年份:2009
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负责人:Sandeep Dave
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依托单位:
Cancer Genetics and Genomics Program
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批准号:10544830
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项目类别:
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资助金额:$7.27万
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财政年份:1997
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负责人:Sandeep Dave
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依托单位:
Cancer Genetics and Genomics Program
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批准号:10323313
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项目类别:
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资助金额:$7.27万
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财政年份:1997
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负责人:Sandeep Dave
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依托单位:
海外基金