Optical Aberration and Visual Performance for Highly Aberrated Eyes

 描述(申请人提供)：本次竞争性更新的目标是将波前引导的巩膜隐形眼镜的实验室研究转化为高度像差眼睛的临床解决方案，使视网膜图像质量恢复到正常或更好的水平。这将通过识别和消除目前使临床翻译复杂化的障碍来实现。这一目标的完成将使研究团队能够检验以下假设：1)A 成熟的视觉系统(在形成期经历了良好的视网膜图像质量)，现在由于高阶像差升高而习惯性地经历较差的视网膜图像质量，将随着时间的推移，恢复到正常的视觉表现水平(视力、对比敏感度作为字母大小和立体锐度的函数)；和2)由波前引导矫正提供的正常或更好的视网膜图像质量，与临床上可用的非波前引导矫正相比，改善了高度像差眼睛的生活质量。

 DESCRIPTION (provided by applicant): The goal of this competitive renewal is to translate laboratory research on wavefront-guided scleral contact lenses into a clinical solution for highly aberrated eyes that restores retinal image quality to normal or better than normal levels. This will be accomplished by identifying and removing barriers that currently complicate clinical translation. Completion of this goal will allow the research team to test the hypotheses that: 1) A mature visual system (having experienced good retinal image quality during the formative years) that is now habitually experiencing poor retinal image quality due to elevated higher order aberrations will, with time, adapt back to normal levels of visual performance (visual acuity, contrast sensitivity as a function of letter size and stereo-acuity); and 2) normal or better than normal retinal image quality provided by wavefront guided corrections improves quality of life in patients with highly aberrated eyes compared to clinically available non-wavefront guided corrections.