Core A: Biostatistics and Bioinformatics Core

项目摘要-核心A 生物统计学和生物信息学核心的目的是提供一个全面的，多学科的 生物统计学和生物信息学方面的专业知识资源。核心A的成员将与 每个项目的调查人员将他们的假设转化为可检验的统计假设， 在调查的各个层面都有相应的目标。这包括设计基础和动物实验， 管理和维护所得数据、数据分析以及统计和生物信息学推断，以及 根据从勘探和可视化的综合发现制定新的假设 数据核心A作为研究者可以从中汲取统计学和生物信息学专业知识的联络点 规划，管理和分析他们的研究。它还开发，测试和实施各种 统计分析技术，包括数学建模，适用于癌症研究。类型的 资助的研究包括基础科学和转化研究。大量的信息将被 在拟议的研究项目和核心产生的，需要计算机为基础的工具， 努力和数据管理。核心A的主要作用是提供最先进的生物统计学 和生物信息学方法和软件管道进行有效的数据分析，并建立一个集中的 一种关系数据库系统和数据管理结构，便于所有数据的输入、存储和检索 数据生成的程序项目，并允许控制的信息交换，在几个 项目和核心。所有与该项目相关的研究者都可以获得去识别信息 项目由于此核心存储的信息的敏感性，我们将采取广泛的预防措施， 保护参与者的隐私。将严格执行所有IRB和HIPAA法规。通过提供 数据访问研究者，分享技术能力，并确保数据的质量，数据 这一核心的管理部分将促进实现项目目标，并鼓励探索 这些分析超出了上述范围。

Project Summary - Core A The purpose of the Biostatistics and Bioinformatics Core is to provide a comprehensive, multi-disciplinary resource of expertise in biostatistics and bioinformatics. Members of Core A will collaborate closely with investigators from each project in translating their hypotheses into testable statistical hypotheses and address the corresponding aims at all levels of investigation. This consists of designing basic and animal experiments, managing and maintaining the resulting data, data analysis and statistical and bioinformatics inference, and formulating new hypotheses based on discoveries arising from exploration and visualization of the integrated data. Core A serves as a focal point from which investigators may draw statistical and bioinformatics expertise for planning, management and analysis of their studies. It also develops, tests and implements various techniques of statistical analysis, including mathematical modeling, applicable to cancer research. Types of research supported include basic science and translational studies. The large volume of information to be generated in the proposed research projects and cores requires computer-based tools for the coordination of efforts and the management of data. The primary role of Core A will be to provide state-of-art biostatistics and bioinformatics methods and software pipelines for efficient data analysis and establish a centralized relational database system and data management structure that facilitates the entry, storage and retrieval of all data generated by the program project, and permits the controlled exchange of information across the several projects and cores. De-identified information will be available to all investigators associated with this program project. Due to the sensitive nature of the information stored by this Core, we will take extensive precautions to protect the confidentiality of participants. All IRB and HIPAA regulations will be strictly enforced. By providing data access to investigators, sharing technical capabilities, and ensuring the quality of the data, the data management component of this core will facilitate achievement of the project aims and encourage exploratory analyses beyond those stated.