Chemical and Structural Biology Program - CSB

化学和结构生物学（CSB）-项目总结/摘要 详细了解生物系统中的分子功能需要有关3D结构的信息 大分子。从这些研究中获得的丰富信息提供了新颖而有力的 洞察功能。化学生物学，通过小分子调节蛋白质功能， 化合物来探索生物学功能以及临床新疗法。成像的工具， 检测和药物递送从化学生物学的努力中出现。结构生物学和 化学生物学系汇集了两个讲同一种语言的群体，即分子生物学语言。 结构，使其成为一个自然的分组。化学与结构生物学（CSB） 该计划旨在促进这种对话，以加速对癌症的理解，检测和治疗。 项目负责人是John H。Bushweller博士，分子生理学和生物物理学教授， 共同负责人是凯文·R Lynch博士，药理学、生物化学和分子遗传学教授。 该计划目前由来自七个不同部门的23名成员和6名准成员组成 在弗吉尼亚大学三所不同的学校里这包括化学系，提供独特的交叉- 校园机会将化学的力量应用于癌症。其中6人是 自从上次续约后就被招进弗吉尼亚大学了该计划的校外资金总额超过1200万美元，其中包括 来自NCI的240多万美元和来自其他NIH研究所的870多万美元。小组成员非常依赖巨蟹座 中心支持的基础设施，特别是生物分子分析核心和核磁共振仪器。试点 CSB成员的赠款支持显示了几个NCI资助赠款的明显投资回报 最初由试点赠款支持的工作产生。许多活动和互动导致了 276份出版物，其中18%为计划间出版物，18%为计划内出版物 自上次更新以来，

CHEMICAL AND STRUCTURAL BIOLOGY (CSB) – PROJECT SUMMARY/ ABSTRACT Detailed understanding of molecular function in biological systems requires information about the 3D structures of macromolecules. The wealth of information available from such studies provides novel and powerful insights into function. Chemical biology, the modulation of protein function by small molecules, provides tool compounds to explore biological function as well as novel therapeutics for the clinic. The tools of imaging, detection, and drug delivery emerge from chemical biology efforts. The merging of the structural biology and chemical biology faculty brings together two groups that speak the same language, the language of molecular structure, making this a natural grouping. The overarching goal of the Chemical & Structural Biology (CSB) Program is to facilitate this dialogue in ways that accelerate understanding, detection, and treatment of cancer. The Program leader is John H. Bushweller, PhD, Professor of Molecular Physiology and Biological Physics, and the co-leader is Kevin R. Lynch, PhD, Professor of Pharmacology and Biochemistry & Molecular Genetics. The Program currently consists of 23 members and 6 associate members from seven different departments spanning three different schools at UVA. This includes the Chemistry Department, providing unique cross- campus opportunities to bring the power of chemistry to bear on cancer. Six of these individuals were recruited to UVA since the last renewal. Total extramural funding for the Program exceeds $12M, including over $2.4M from the NCI and over $8.7M from other NIH institutes. The group members rely heavily on Cancer Center supported infrastructure, particularly the Biomolecular Analysis Core and NMR instrumentation. Pilot grant support of CSB members has shown a clear return on investment with several NCI funded grants emerging from work supported originally with pilot grant support. The many activities and interactions have led to 276 publications, of which 18% were inter-programmatic publications and 18% were intra-programmatic publications since the last renewal.